ZAK Antibody

說明書

中文名稱：

ZAK兔多克隆抗體
貨號：

CSB-PA030032
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NYL2
基因名：

MAP3K20
別名：

AZK antibody; Cervical cancer suppressor gene 4 protein antibody; HCCS 4 antibody; HCCS-4 antibody; HCCS4 antibody; Human cervical cancer suppressor gene 4 protein antibody; Leucine zipper and sterile alpha motif containing kinase antibody; Leucine zipper- and sterile alpha motif-containing kinase antibody; Mitogen activated protein kinase kinase kinase MLT antibody; Mitogen-activated protein kinase kinase kinase MLT antibody; Mixed lineage kinase 7 antibody; Mixed lineage kinase related kinase antibody; Mixed lineage kinase related kinase MRK beta antibody; Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody; Mixed lineage kinase-related kinase antibody; MLK 7 antibody; MLK like mitogen activated protein triple kinase antibody; MLK related kinase antibody; MLK-like mitogen-activated protein triple kinase antibody; MLK-related kinase antibody; MLK7 antibody; Mlklak antibody; MLT antibody; MLTK_HUMAN antibody; MRK antibody; Sterile alpha motif and leucine zipper containing kinase AZK antibody; Sterile alpha motif- and leucine zipper-containing kinase AZK antibody; Zak antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from Human MLTK around the non-phosphorylation site of S165.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development.; Phosphorylates histone H3 at 'Ser-28'. May have role in neoplastic cell transformation and cancer development. Causes cell shrinkage and disruption of actin stress fibers.
基因功能參考文獻：
1. The ZAK rs3769201 and rs722864 may be functional susceptibility loci for lung cancer risk. PMID: 29071797
2. The expression of ZAKbeta is dependent on ZAKalpha expression, and ZAKbeta further enhances ZAKalpha expression and results in synergistic enhancement of apoptosis in osteosarcoma cells. PMID: 29654619
3. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers. PMID: 26522728
4. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy. PMID: 27816943
5. ZAK is a key player in mammalian limb patterning in humans and mice. PMID: 26755636
6. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers. PMID: 24807215
7. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK pathway. PMID: 25013376
8. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK) PMID: 24170769
9. MRK is a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38 PMID: 23319595
10. The genes identified KTN1, ROCK1, and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone PMID: 21305317
11. decrease of lung cancer cell proliferation by ZAK may involve the ERK and JNK pathways via an AP-1 transcription factor. PMID: 20331627
12. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1, and show that MRK-beta could also activate MSK1 through direct interaction. PMID: 20408143
13. Results suggest that ZAK might play a role as an upstream signal to suppress the ZZaPK function and decrease E2F expression. PMID: 12535642
14. Data show that in response to radiation, MRK controls two independent pathways: the Chk2-Cdc25A pathway leading to cell cycle arrest and the p38gamma MAPK pathway PMID: 15342622
15. Results suggest that a ZAK mediates TGF-beta-induced cardiac hypertrophic growth via a novel TGF-beta signaling pathway. PMID: 15465036
16. ZAK induces characteristic hypertrophic growth features, including increased cell size, elevated atrial natriuretic factor expression, and increased actin fiber organization PMID: 15485649
17. Mixed lineage kinase 7 (MLK7), a splice variant of the ZAK gene, encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation. PMID: 15737997
18. data demonstrate that a ZAK isoform(s) is the MAP3Kinase that transduces the ribotoxic stress response PMID: 18331592
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相關疾病：

Split-foot malformation with mesoaxial polydactyly (SFMMP)
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
組織特異性：

Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
數據庫鏈接：

HGNC: 17797

OMIM: 609479

KEGG: hsa:51776

STRING: 9606.ENSP00000364361

UniGene: Hs.444451

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