YWHAE Antibody

說明書

中文名稱：

YWHAE兔多克隆抗體
貨號：

CSB-PA072462
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA072462(YWHAE Antibody) at dilution 1/5, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA072462(YWHAE Antibody) at dilution 1/5, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-4: Hela cells, 293T cells, Human fetal brain tissue, Mouse brain tissue, Primary antibody: CSB-PA072462(YWHAE Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P62258
基因名：

YWHAE
別名：

14 3 3 E antibody; 14 3 3 epsilon antibody; 14 3 3E antibody; 14-3-3 protein epsilon antibody; 14-3-3E antibody; 1433E_HUMAN antibody; Epididymis luminal protein 2 antibody; FLJ45465 antibody; FLJ53559 antibody; HEL2 antibody; KCIP 1 antibody; KCIP1 antibody; MDCR antibody; MDS antibody; Mitochondrial import stimulation factor L subunit antibody; Protein kinase C inhibitor protein1 antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; epsilon antibody; Tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein; epsilon polypeptide antibody; Tyrosine 3/tryptophan 5 monooxygenase activation protein epsilon polypeptide antibody; YWHAE antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human YWHAE
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:500-1:10000
WB	1:500-1:2000
IHC	1:5-1:20

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm.
基因功能參考文獻：
1. results support YWHAE being a risk gene for Major Depressive Disorder in the Han Chinese population. PMID: 28414084
2. YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells. PMID: 27863420
3. we report recurrent BCOR exon 16 internal tandem duplications and YWHAE-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas. PMID: 26945340
4. For metastatic YWHAE-rearranged HG-ESS, prolonged disease control following diagnosis was seen, with notable responses to anthracycline-based therapy. This emphasizes the need for appropriate molecular testing of uterine mesenchymal malignancies. PMID: 28390819
5. phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation. PMID: 27514745
6. The 14-3-3 family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon, theta and zeta isoforms could be useful indicators of disease severity. PMID: 27030512
7. Studies show that patients with clear cell sarcoma of the kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young, had low tumor volumes, and did not present with stage I disease which fail to identify an explicit clinical phenotype. PMID: 26542179
8. Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I) to the adaptor MAVS protein and thereby blocked antiviral signaling. PMID: 26998762
9. Report mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney. PMID: 27000436
10. CEP131 is the key regulatory target of MK2 and 14-3-3 in centriolar satellite remodeling. PMID: 26616734
11. 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis. PMID: 26208633
12. DAPK2-induced apoptosis is negatively regulated by Akt and 14-3-3 proteins. PMID: 26047703
13. These data demonstrate a novel role for HDAC6 in controlling 14-3-3zeta binding activity. PMID: 25770209
14. YWHAE-FAM22 rearrangement is associated with endometrial stromal sarcomas. PMID: 25244606
15. Results suggest a specific role for YWHAE single nucleotide polymorphisms in the pathophysiology of schizophrenia. PMID: 25105667
16. Cleft lip/palate has been found associated with 17p13.3 duplication involving a single candidate gene (YWHAE) in a father and his son. PMID: 23901910
17. Data show that two isoforms of the 14-3-3 family, 14-3-3epsilon and 14-3-3 gamma, can stabilize Cdt2 independent of each other when overexpressed. PMID: 25154416
18. These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern in patients with schizophrenia. PMID: 24561237
19. data indicate that 14-3-3 is required for Bim expression and that it has an anti-cancer effect under pERK1/2 inhibition in 143B cells PMID: 24536031
20. for endometrial sarcoma cases with high-grade morphology we recommend to test for YWHAE rearrangements by FISH break-apart PMID: 23599159
21. YWHAE polymorphisms may be a genetic risk factor for HIV-associated neurocognitive disorder (HAND). PMID: 23982958
22. Data indicate that 14-3-3 zeta, gamma, epsilon, and tau isoforms but not the sigma protein hydrolyze ATP. PMID: 24269678
23. Carriers of the YWHAE*C allele of rs3752826 polymorphism have increased risk of suicidal behavior. PMID: 24450199
24. findings suggest that FAK expression is correlated with and upregulated by 14-3-3epsilon via activation of NFkappaB PMID: 22934705
25. interaction between NAV2 and 14-3-3epsilon PMID: 24161943
26. 14-3-3epsilon associates with TAK1 in a phosphorylation-dependent manner to determine the cell fate of Bleomycin-treated HCC cells PMID: 23472066
27. YWHAE gene duplication is associated with developmental, behavioral and brain abnormalities. PMID: 23813913
28. 14-3-3epsilon may act as an important regulator in modulating tumor metastasis by promoting epithelial-mesenchymal transition as well as cell migration. PMID: 23483955
29. The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent. PMID: 23271436
30. The ERK/MAPK pathway is involved in the pathogenesis of gastric cancer; RKIP and 14-3-3epsilon exert an opposite effect on this pathway and the cells possibly via both direct and indirect reactions with the elements in this pathway. PMID: 22899242
31. the -458G>T YWHAE variant contributes to the abnormal myocardial morphogenesis characteristic of LVNC as well as abnormal brain development, and implicate YWHAE as a novel candidate gene in pediatric cardiomyopathies. PMID: 23266643
32. YWHAE gene contribute to the phenotype of small 17p13.3 chromosomal duplication in Miller-Dieker syndrome PMID: 23035971
33. results suggest that YWHAE does play a major role in bipolar disorder in the Han Chinese population. PMID: 23140658
34. These results showed that IgE is produced during malaria, and that the negative correlation between levels of IgE to 14-3-3 epsilon protein and parasitemia in asymptomatic malaria supports a role for these IgE molecules in defense mechanisms. PMID: 22984113
35. Data obtained, which have never previously been reported, were used to modify the published 14-3-3 crystal structure using molecular modeling. PMID: 22580067
36. When evaluating high-grade uterine sarcomas, cyclin D1 can be included in the immuno-histochemical panel as an indicator of YWHAE-FAM22endometrial stromal sarcoma. PMID: 22982899
37. results indicate that the dosage effect of YWHAE varies from severe to very mild structural brain abnormalities, and suggest that the expression of YWHAE is associated with a complex mechanism of neuronal development PMID: 22887762
38. 14-3-3epsilon is essential for the stable interaction of RIG-I with TRIM25, which facilitates RIG-I ubiquitination and initiation of innate immunity against hepatitis C virus and other pathogenic RNA viruses. PMID: 22607805
39. Tumors with YWHAE-FAM22 rearrangements constitute a distinct group of endometrial stromal sarcoma (ESS), which is associated with high-grade morphology and aggressive clinical behavior compared to JAZF1 ESS. PMID: 22456610
40. Collectively, these results identify a novel locus of apoptosomal regulation wherein MAPK signalling promotes Rsk-catalysed Apaf-1 phosphorylation and consequent binding of 14-3-3varepsilon, resulting in decreased cellular responsiveness to cytochrome c. PMID: 22246185
41. Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry. PMID: 22151054
42. Fluorescence in situ hybridization analysis demonstrated absolute specificity of YWHAE-FAM22A/B genetic rearrangement for high-grade endometrial stromal sarcoma. PMID: 22223660
43. YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese populatio PMID: 21184166
44. Data suggest a regulatory circuitry involving Smad4 dependent up-regulation of KRT23 (directly or indirectly) which in turn modulates the interaction between KRT23 and 14-3-3epsilon leading to a cytoplasmic sequestration of 14-3-3epsilon. PMID: 21492476
45. Results suggest that ERK and p38 MAPK regulate subcellular localization of Prdx6 by activation of 14-3-3epsilon as a chaperone protein, resulting in its translocation to acidic organelles. PMID: 21346153
46. Overexpression of 14-3-3epsilon predicts tumour metastasis and poor survival in hepatocellular carcinoma PMID: 21401702
47. For the first time, we found that TNF-alpha stimulation enhances the interactions between 14-3-3 epsilon and some key components in the mitogen-activated protein kinase (MAPK) signal module which is located at the immediate upstream of NF-kappaB. PMID: 20462248
48. The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma. PMID: 20388496
49. Decreased expression of 14-3-3epsilon in contributes to the initiation and progression of laryngeal carcinoma by affecting apoptosis and invasion. PMID: 20565895
50. the identification of a novel splicing variant of human 14-3-3 epsilon (14-3-3 epsilon sv), derived from a novel exon 1' insertion is reported. PMID: 20417184
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亞細胞定位：

Nucleus. Cytoplasm. Melanosome.
蛋白家族：

14-3-3 family
數據庫鏈接：

HGNC: 12851

OMIM: 605066

KEGG: hsa:7531

STRING: 9606.ENSP00000264335

UniGene: Hs.513851

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