XDH Antibody
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中文名稱：XDH兔多克隆抗體
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貨號：CSB-PA026189GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：XDH
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別名：Xanthine dehydrogenase antibody; Xanthine dehydrogenase/oxidase antibody; Xanthine oxidase antibody; Xanthine oxidoreductase antibody; XD antibody; XDH antibody; XDH_HUMAN antibody; xdha antibody; XO antibody; xor antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human XDH
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
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基因功能參考文獻：
- The information represented in the study confirmed previous reports. And it may assist to discover and design new backbones as potential XO inhibitors based on natural products. PMID: 29843539
- The role of xanthine oxidoreductase and uric acid in metabolic syndrome. PMID: 29733945
- Data found that gastric cancer patients adhering to the SNP rs207454 CC genotype had favorable clinical outcome compared with those carrying the AA/AC genotypes, suggesting that the CC allele was a protective allele in the prognosis of gastric cancer by effecting XDH mRNA expression level. PMID: 29551504
- this study shows that XOR is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity PMID: 27494876
- Molecular docking simulations clarified that purpurogallins have stronger affinities for XO than corresponding pyrogallols. These results revealed that the potent XO inhibitory activity seemingly observed in pyrogallol is actually derived from its chemical conversion, under alkaline conditions, into purpurogallin. PMID: 28223196
- data suggest that Alcohol use disorders augment pulmonary and systemic XOR activity that may contribute to ROS and uric acid generation, promoting inflammation. PMID: 28839105
- XO is a useful marker to assess oxidative stress in polycystic ovary syndrome patients PMID: 27295433
- xanthine dehydrogensase gene expression and uric acid production is altered in asthma and in human airway epithelial cells PMID: 28863172
- Among cardiac patients, left ventricular hypertrophy, low LVEF, and increased BNP were significantly associated with plasma XOR activity independent of various confounding factors. PMID: 28797123
- we demonstrated that BP rise over time and/or the risk of hypertension are associated with three SNP in the XOR gene: rs2043013, rs11904439, and rs148756340. PMID: 27607461
- Hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury in kidney allograft recipients. PMID: 28031169
- Serum XOD activity was higher in type 2 DM patients than in control subjects and was higher in diabetic patients with diabetic peripheral neuropathy than in those without neuropathy. PMID: 27965983
- XOR activity is correlated with insulin resistance, BMI, and subclinical inflammation. PMID: 28403945
- Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis. PMID: 28299863
- Results show XOR strictly modulated at the transcriptional and post-translational levels, and its expression and activity are highly variable in cancer and negatively associated with high malignity grade and a worse prognosis. [review] PMID: 26687331
- XDH and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease. PMID: 26863601
- beneficial effects observed with XO inhibitors on cardiovascular disease in chronic kidney disease may also be due to the reduction of oxidative stress PMID: 26426087
- Thyroid stimulating hormone levels are increase in gout patients treated with inhibitors of xanthine oxidoreductase. PMID: 26342297
- The XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension in a rural Chinese population. PMID: 26239312
- genetic association studies in population in Mexico: Data suggest that SNPs in XO (1936A>G, 2107A>G) are not associated with development of typical adverse reactions to methotrexate in pediatric patients with ALL (acute lymphoblastic leukemia). PMID: 26353179
- the essential role of autophagy-regulated early ROS in triggering late apoptotic signaling PMID: 26029922
- XOR regulated macrophage IL-1b secretion upon NLRP3 inflammasome activation via xanthine oxidase derived reactive oxygen species. PMID: 25800347
- In this review, we focus on studies of XOR inhibitors and their implications for understanding the chemical nature and reaction mechanism of the Moco active site of XOR PMID: 25501928
- xanthine oxidase-mediated ROS production is required for PTN-induced cell migration through the cell membrane functional complex of alphanubeta3 and RPTPbeta/zeta and activation of c-src, PI3K and ERK1/2 kinases PMID: 25582077
- Data suggest that, with aging, up-regulation of reactive oxygen species derived from XO down-regulates uric acid excretion via down-regulation of active homodimer breast cancer resistance protein (BCRP1, uric acid efflux transporter) in ileal mucosa. PMID: 26119820
- Xanthine oxidase is activated in THP-1 human myeloid cells in response to pro-inflammatory and growth factor stimulation. PMID: 25200751
- Xanthine oxidoreductase has roles in atherosclerosis pathogenesis [review] PMID: 25463089
- Xanthine dehydrogenase takes part in retinoic acid biosynthesis in the thyroid glandular epithelia. PMID: 24506204
- The polymorphisms rs1052133 on OGG1 and rs207454 on XDH show a trend of association with overall survival. PMID: 23443115
- Results confirm the role of XO enzyme in ischemic heart disease. PMID: 24092361
- These results supported the possibility that XO/XD and AO can contribute to nitric oxide generation. PMID: 25537183
- XO is present in the pathogenesis of metabolic syndrome. PMID: 24967004
- In infection with E. coli both XO and MPO urine levels were increased. PMID: 24591758
- these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis PMID: 25044064
- XOR activity is significantly associated with NAFLD PMID: 25185415
- This study reveals a noncanonical molecular pathway in which, after the inhibition of cathepsin S, autophagy induces early reactive oxygen species production for oxidative DNA damage and cell death through xanthine oxidase. PMID: 23892358
- An upregulated XOD may be implicated in hrmodialysis-induced oxidative injury. PMID: 23819009
- xanthine oxidoreductase may have a function in the formation or persistence of chronic wounds PMID: 24357442
- Inhibition of XO increased survival of human embryo brain-derived cells in culture. . There was a a reversed correlation between the activities of XO and DPD over 12 days under normal conditions as well as in the presence of XO and DPD inhibitors. PMID: 23597150
- Case Report: hereditary xanthinuria with xanthine dehydrogenase deficiency due to novel sequence variations presenting as rheumatoid arthritis. PMID: 20077140
- Xanthine dehydrogenase/oxidase is a moonlighting protein that has two distinct catalytic activities as a dehydrogenase and an oxidase. PMID: 17301077
- SNPs at the 5'-nucleotidase and xanthine oxidase genes influence the risk of noncirrhotic portal hypertension in HIV patients treated with didanosine. PMID: 23315321
- Data suggest that XOD is up-regulated in lens of patients with (1) diabetes type 2 with cataracts and (2) senile cataracts; blood HbA1C levels (or poor glycemic control) are positively correlated with lens XOD activity as well as serum XOD activity. PMID: 23142692
- Site-directed mutagenesis followed by expression analysis in Escherichia coli revealed that not only the frame shift mutation 141insG impairs XDH activity, but also the missense mutation C2729T. PMID: 22981351
- Xanthine oxidase released during enteropathogenic Escherichia coli and Shiga-toxigenic Escherichia coli infection may serve as a virulence-inducing signal to the pathogen and not solely as a protective host defense. PMID: 23340314
- Xanthinuria Type I is caused by mutations in the xanthine dehydrogenase gene (XDH). We report on a patient suffering from xanthinuria. Genomic DNA was screened for point mutations and imbalances in the XDH gene by sequencing and microarray typing. PMID: 23249873
- XDH genetic polymorphisms may influence azathioprine treatment outcome in patients with kidney transplants. PMID: 22495427
- There was no significant difference in XO activity between Swedes and Koreans PMID: 22105431
- high tumoral XDH expression is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung. PMID: 22678977
- The results indicated that anti-HXOR antibodies in synovial fluids have a protective role as high concentrations against XOR were detected in inflammatory arthritis. PMID: 21644044
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相關(guān)疾病：Xanthinuria 1 (XAN1)
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亞細胞定位：Cytoplasm. Peroxisome. Secreted.
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蛋白家族：Xanthine dehydrogenase family
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組織特異性：Detected in milk (at protein level).
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