WSS1 Antibody, HRP conjugated

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說明書

中文名稱：

WSS1兔多克隆抗體, HRP偶聯(lián)
貨號：

CSB-PA334485LB01SVG
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Saccharomyces cerevisiae WSS1 Polyclonal antibody
Uniprot No.：

P38838
基因名：

WSS1
別名：

WSS1 antibody; YHR134WDNA-dependent metalloprotease WSS1 antibody; EC 3.4.24.- antibody; DNA damage response protein WSS1 antibody; SUMO-dependent isopeptidase WSS1 antibody; Weak suppressor of SMT3 protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Saccharomyces cerevisiae
免疫原：

Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)
免疫原種屬：

Saccharomyces cerevisiae
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
基因功能參考文獻：
1. e show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs PMID: 27852435
2. Data suggest that Wss1 contributes to survival of DNA-protein crosslink (DPC)-harboring cells by acting on DPCs proteolytically. Wss1 enables replication of DPC-containing DNA and thus promotes genome integrity. PMID: 24998930
3. Involement of WSS1 in the DNA damage response. PMID: 15598824
4. In dividing cells, Wss1 is exclusively present in the mother cell. PMID: 18336552
亞細胞定位：

Nucleus. Note=Present in a single sharp spot near the nuclear membrane, distinct from the spindle pole bodies and nucleolus. In dividing cells, the spot is exclusively present in the mother cell.
蛋白家族：

Peptidase M3 family, WSS1-like metalloprotease (WLM) subfamily
數(shù)據(jù)庫鏈接：

KEGG: sce:YHR134W

STRING: 4932.YHR134W

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