WIPF2 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) WIPF2 Polyclonal antibody
Uniprot No.：

Q8TF74
基因名：

WIPF2
別名：

WIPF2 antibody; WICH antibody; WIRE antibody; PP10631 antibody; WAS/WASL-interacting protein family member 2 antibody; WASP-interacting protein-related protein antibody; WIP- and CR16-homologous protein antibody; WIP-related protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human WAS/WASL-interacting protein family member 2 protein (18-176AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.
基因功能參考文獻：
1. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation. PMID: 27009365
2. Data indicate that the reduced vimentin expression in response to EPHB4, WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels. PMID: 23295955
3. The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor PMID: 12213210
亞細胞定位：

Cytoplasm, cytoskeleton. Note=Localized to stress fibers and bundles of actin filaments.
蛋白家族：

Verprolin family
組織特異性：

Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta.
數據庫鏈接：

HGNC: 30923

OMIM: 609692

KEGG: hsa:147179

STRING: 9606.ENSP00000320924

UniGene: Hs.421622

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