USP44 Antibody
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中文名稱：USP44兔多克隆抗體
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貨號：CSB-PA060300
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規格：￥1090
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圖片：
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Western Blot analysis of 293T cells using USP44 Polyclonal Antibody -
Western blot analysis of mouse-kidney lysis using USP44 antibody.
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其他：
產品詳情
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Uniprot No.：
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基因名：USP44
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別名：Deubiquitinating enzyme 44 antibody; E430004F17Rik antibody; Ubiquitin carboxyl-terminal hydrolase 44 antibody; ubiquitin specific peptidase 44 antibody; Ubiquitin thiolesterase 44 antibody; Ubiquitin-specific-processing protease 44 antibody; UBP44_HUMAN antibody; USP44 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human USP44.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
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基因功能參考文獻：
- These data imply a complex picture where regulating factors such as OCT4 may interact with other epigenetic mechanisms to regulate USP44 expression in pluripotent stem cells and testes. PMID: 28520534
- USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size PMID: 28492742
- In summary, we report that the combination of USP44 expression and DNA ploidy status might serve as an independent prognostic marker in gastric cancer. PMID: 28544703
- USP44 contributes to N-CoR functions in regulating gene expression and is required for efficient invasiveness of triple-negative breast cancer cells. PMID: 27880911
- USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry PMID: 26232424
- USP44 is epigenetically inactivated in colorectal adenomas, but this alone is not sufficient to cause aneuploidy in colorectal neoplasia. PMID: 24837038
- findings implicate USP44 in negative regulation of the RNF8/RNF168 pathway PMID: 23615962
- Data identify Cdc20, USP44, and Wee1 as relevant Fcp1 targets. PMID: 22692537
- These data are consistent with an important role for USP44 in regulating Cdc20-APC/C activity and suggest that high levels of this enzyme may contribute to the pathogenesis of T-cell leukemias. PMID: 21853124
- a dynamic balance of ubiquitination by the APC and deubiquitination by USP44 contributes to the generation of the switch-like transition controlling anaphase entry PMID: 17443180
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亞細胞定位：Nucleus.
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蛋白家族：Peptidase C19 family, USP44 subfamily
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組織特異性：Expressed in testis. Expressed at high levels in T-cell acute lymphoblastic leukemia.
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數據庫鏈接：
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