USP30 Antibody

中文名稱：

USP30兔多克隆抗體
貨號：

CSB-PA765106LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human Kidney tissue using CSB-PA765106LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA765106LA01HU at dilution of 1:100
其他：

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靶點詳情

產品詳情

產品描述：

The polyclonal antibody against USP30 was created in rabbits through immunization with recombinant human USP30 protein containing amino acids 101-400. This USP30 polyclonal antibody is only reactive with USP30 protein from human samples. The deubiquitinase enzyme USP30 is responsible for the regulation of protein turnover and maintenance of mitochondrial function.

The USP30 antibody has been purified via protein G affinity chromatography, achieving more than 95% purity. Its validation in ELISA and IHC applications has further enhanced its versatility in experimental settings.
產品名稱：

Rabbit anti-Homo sapiens (Human) USP30 Polyclonal antibody
Uniprot No.：

Q70CQ3
基因名：

USP30
別名：

Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，USP30 Antibody (CSB-PA765106LA01HU)，的標記方式是Non-conjugated。對于USP30 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA765106LB01HU	USP30 Antibody, HRP conjugated	ELISA
FITC	CSB-PA765106LC01HU	USP30 Antibody, FITC conjugated
Biotin	CSB-PA765106LD01HU	USP30 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
基因功能參考文獻：
1. the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
2. Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
3. show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
4. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
5. The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
6. reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
7. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522
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亞細胞定位：

Mitochondrion outer membrane.
蛋白家族：

Peptidase C19 family
組織特異性：

Expressed in skeletal muscle, pancreas, liver and kidney.
數據庫鏈接：

HGNC: 20065

OMIM: 612492

KEGG: hsa:84749

STRING: 9606.ENSP00000257548

UniGene: Hs.486434

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