USP26 Antibody

說明書

中文名稱：

USP26兔多克隆抗體
貨號：

CSB-PA874835ESR1HU
規格：

￥440
圖片：
Western blot
All lanes: USP26 antibody at 5.22µg/ml
Lane 1: Hela whole cell lysate
Lane 2: U937 whole cell lysate
Lane 3: Mouse gonadal tissue
Lane 4: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 105 kDa
Observed band size: 105 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA874835ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA874835ESR1HU at dilution of 1:100
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靶點詳情

產品詳情

產品描述：

The USP26 antibody is produced by immunizing rabbits with the recombinant human USP26 protein (664-913AA) and then antigen-affinity-purified from rabbit antiserum. It occurs as an unconjugated IgG. It shows reactivity with human and mouse USP26 protein, a deubiquitylating enzyme that plays a negatively regulatory function in cellular reprogramming and is required for embryonic stem cell (ESC) differentiation. This USP26 antibody has been validated for use in ELISA, WB, and IHC applications.
產品名稱：

Rabbit anti-Homo sapiens (Human) USP26 Polyclonal antibody
Uniprot No.：

Q9BXU7
基因名：

USP26
別名：

Deubiquitinating enzyme 26 antibody; MGC120066 antibody; MGC120067 antibody; MGC120068 antibody; Ubiquitin carboxyl terminal hydrolase 26 antibody; Ubiquitin carboxyl-terminal hydrolase 26 antibody; Ubiquitin specific peptidase 26 antibody; Ubiquitin specific processing protease 26 antibody; Ubiquitin specific protease 26 antibody; Ubiquitin thioesterase 26 antibody; Ubiquitin thiolesterase 26 antibody; Ubiquitin-specific-processing protease 26 antibody; UBP26_HUMAN antibody; USP 26 antibody; USP26 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 26 protein (664-913AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
基因功能參考文獻：
1. findings demonstrate TGF-beta enhances expression of USP26 and reinforces SMAD7 stability by limiting the ubiquitin-mediated turnover of SMAD7; clinically, loss of USP26 correlates with high TGF-beta activity and confers poor prognosis in glioblastoma; data identify USP26 as a novel negative regulator of the TGF-beta pathway and suggest that loss of USP26 expression may be an important factor in glioblastoma pathogenesis PMID: 28381482
2. Data show that USP26 interacts with PRC1 components chromobox (CBX)-containing proteins CBX4 and CBX6. PMID: 28839133
3. A novel USP26 variant p.R344W is associated with nonobstructive azoospermia probably through affecting androgen receptor function. PMID: 27089915
4. The interaction between USP26 and Mdm2, and the subsequent deubiquitination of Mdm2, serves, most probably to regulate Mdm2. Future therapeutic modalities that interfere with the association between USP26 and Mdm2 will be used to destabilize the ligase in malignancies where it is upregulated. PMID: 27810359
5. identification in a normozoospermic man of a nonsense mutation (c.882C>A) which causes the production of a truncated protein, suggests a marginal role of USP26 in male spermatogenesis PMID: 27726449
6. Evidence from both enzymatic and meta-analyses does not support a direct association between USP26 variants and male infertility PMID: 25755145
7. There is an association of alteration in USP26 with male infertility, especially in azoospermia and in the Asian population. [Meta-Analysis] PMID: 24875820
8. there is a significant difference in USP26 gene expression between the obstructive azoospermia, complete maturation arrest samples and Sertoli Cell-Only Syndrome samples PMID: 23779098
9. results indicated the variation of USP26 was not directly associated with human sperm count but suggested it might be a potential role in sperm motility PMID: 21147082
10. The nucleotide polymorphisms of the Usp26 gene might be closely related with idiopathic male infertility, and exert a negative effect on the testis function. PMID: 22568204
11. USP26 assembles with androgen receptors (AR)and other cofactors in subnuclear foci and serves to counteract hormone-induced AR ubiquitination, thereby contributing to the regulation of AR transcriptional activity. PMID: 20501646
12. Alterations in the USP26 gene may be involved in male infertility or might increase the risk of male infertility. These patients showed 370-371insACA, 494T>C and 1423C>T causing T123-124ins, L165S and H475Y, respectively PMID: 15562280
13. The USP26 gene may be of importance in male reproduction. Mutations in this gene may be associated with male infertility, and may negatively affect testicular function. PMID: 15970005
14. USP26 haplotype is present in significant frequencies in sub-Saharan African and South and East Asian populations, including in individuals with known fertility. This indicates that the allele is not associated with infertility. PMID: 16888075
15. Sequencing can confirm the presence of the three changes of the USP26 gene in patients of Caucasian origin with cryptozoospermia or oligozoospermia. PMID: 17121659
16. The USP26 gene might be of importance in male reproduction. Mutations in this gene might be associated with male infertility, and might negatively affect testicular function. PMID: 17968467
17. Mutations of the USP26 gene do not appear to be a common cause of idiopathic azoospermia or severe oligozoospermia. PMID: 18377898
18. Mutation within the USP26 gene is associated with risk of inguinal hernia leading to impaired male fertility. PMID: 18927127
19. Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan PMID: 18958354
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亞細胞定位：

Nucleus.
蛋白家族：

Peptidase C19 family
數據庫鏈接：

HGNC: 13485

OMIM: 300309

KEGG: hsa:83844

STRING: 9606.ENSP00000359869

UniGene: Hs.333137

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