USF2 Antibody

說明書

中文名稱：

USF2兔多克隆抗體
貨號：

CSB-PA290775
規格：

￥2024
圖片：
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using USF2 antibody.

Western blot analysis of extracts from HeLa cells, using USF2 antibody.

Western blot analysis of extracts from HeLa cells and HepG2 cells using USF2 antibody. The lane on the left is treated with synthesized peptide.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) USF2 Polyclonal antibody
Uniprot No.：

Q15853
基因名：

USF2
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Internal of Human USF-2.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
基因功能參考文獻：
1. TCF21 modulates Steroidogenic factor-1 and estrogen receptor beta expression through the recruitment of USF2 in endometriotic stromal cells. PMID: 30018006
2. USF2, and its target gene PAI-1, regulate serum-stimulated keratinocyte growth, and likely the cadence of cell cycle progression in replicatively competent cells as part of the injury repair program. PMID: 24905330
3. RNA Pol II on HIF1 or HIF2 target genes is primarily associated with HIF1alpha or HIF2alpha in a STAT3 or USF2 dependent manner PMID: 23991099
4. USF2 functionally interacts with YY1 blocking its inhibitory activity, in favor of CEBPB transactivation. PMID: 23560079
5. USF2 and hypoxia-inducible factor 2alpha (HIF2alpha) cooperatively activate HIF2 target genes during hypoxia. PMID: 22966206
6. Bone morphogenetic proteins and ID1 exerted an anti-apoptotic effect in mesangial cells by inhibition of USF2 transcriptional activity. PMID: 21921026
7. data established that high glucose stimulated USF2 expression in HK-2 cells, at least in part, through angiotensin II-AT1-dependent activation of CREB, which can contribute to diabetic tubulointerstitial fibrosis PMID: 20814220
8. Usf2 mediates quercetin-induced suppression of PAI-1 gene expression in human endothelial cells PMID: 20626032
9. Ddata indicate that USF2 is one of the components of the FoxA1/androgen receptor transcriptional protein complex that contributes to the expression of androgen-regulated and prostate-specific genes. PMID: 19846536
10. Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. Impaired ERK1/2 signalling pathways were activated only by GM-CSF but not by Epo. PMID: 11583024
11. defect in USF function may contribute to down-regulation of IGF2R expression in cancer cells. PMID: 12857727
12. Cotransfection experiments demonstrated that overexpression of upstream stimulatory factor 2 increases cyclic GMP-dependent protein kinase I promoter activity in human vascular smooth muscle cells. PMID: 15741164
13. USF1 and USF2 mRNA levels were reduced in non-small cell lung carcinoma; AP2-alpha levels were elevated; regression analysis demonstrated that reduced USF2 mRNA & increased AP2-alpha mRNA levels were predictive of downregulated PIGR mRNA expressions PMID: 15864740
14. Data show that the elevated levels of USF2 in endometriosis account for, in part, the aberrant expression of SF-1 and its target gene StAR and aromatase. PMID: 18165439
15. down-regulation of hsa-miR-10a may increase USF2 and contribute to the increase in cell proliferation of chronic myeloid leukemia implicating a miRNA in its abnormal behavior PMID: 19074828
16. decreased expression of the Hint1 gene through epigenetic silencing may play a role in enhancing the growth of a subset of human hepatoma by increasing the expression of genes controlled by the transcription factors beta-catenin, USF2, and NFkappaB PMID: 19089909
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亞細胞定位：

Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 12594

OMIM: 600390

KEGG: hsa:7392

STRING: 9606.ENSP00000222305

UniGene: Hs.454534

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