UPK1B Antibody

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UPK1B Polyclonal antibody
Uniprot No.：

O75841
基因名：

UPK1B
別名：

UPK1B; TSPAN2; Uroplakin-1b; UP1b; Tetraspanin-20; Tspan-20; Uroplakin Ib; UPIb
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Uroplakin-1b protein (110-230AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
基因功能參考文獻：
1. Urine UPIb levels may be useful for predicting the risk of recurrent urinary tract infections in patients diagnosed with their first UTI and may also be considered as a noninvasive screening test for vesicoureteral reflux. PMID: 24559587
2. established the genomic organization of the UPIb gene PMID: 12031497
3. Loss of uroplakin Ib expression is associated with bladder carcinomas PMID: 15140401
4. Loss of uroplakin Ib expression by CpG methylation of Sp1/NFkappaB-binding motifs within the proximal promoter is associated with urothelial tumors PMID: 16354592
5. The biopsy-induced increase in the expression of UPIb and other genes encoding membrane proteins supports the possible importance of the membrane structure and stability during implantation. PMID: 18355812
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Tetraspanin (TM4SF) family
組織特異性：

Bladder epithelium.
數據庫鏈接：

HGNC: 12578

OMIM: 602380

KEGG: hsa:7348

STRING: 9606.ENSP00000264234

UniGene: Hs.271580

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