UNC5D Antibody, FITC conjugated
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中文名稱：UNC5D兔多克隆抗體, FITC偶聯
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貨號：CSB-PA740925LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) UNC5D Polyclonal antibody
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Uniprot No.：
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基因名：UNC5D
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別名：UNC5D antibody; KIAA1777 antibody; UNC5H4 antibody; UNQ6012/PRO34692 antibody; Netrin receptor UNC5D antibody; Protein unc-5 homolog 4 antibody; Protein unc-5 homolog D antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Netrin receptor UNC5D protein (90-212AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.
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基因功能參考文獻：
- The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores. PMID: 28754176
- Unc5D is thus a newly identified transcriptional target of proapoptotic p53 and may also act upstream of p53 to induce p53dependent apoptosis by phosphorylation at ser15. PMID: 24691657
- the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma. PMID: 24519068
- UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH. PMID: 23589179
- UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated programmed cell death during neuroblastoma regression. PMID: 23778138
- UNC5H4 amplifies p53-dependent apoptotic response. PMID: 18402767
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Unc-5 family
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數據庫鏈接：
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