UGT1A4 Antibody

說明書

中文名稱：

UGT1A4兔多克隆抗體
貨號：

CSB-PA115333
規格：

￥1100
圖片：
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA115333(UGT1A4 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P22310
基因名：

UGT1A4
別名：

Bilirubin UDP glucuronosyltransferase isozyme 2 antibody; Bilirubin-specific UDPGT isozyme 2 antibody; HUG-BR2 antibody; UD14_HUMAN antibody; UDP glucuronosyltransferase 1 family polypeptide A4 antibody; UDP glycosyltransferase 1 family polypeptide A4 antibody; UDP-glucuronosyltransferase 1-4 antibody; UDP-glucuronosyltransferase 1-D antibody; UDP-glucuronosyltransferase 1A4 antibody; UDPGT 1-4 antibody; UDPGT antibody; UGT-1D antibody; UGT1*4 antibody; UGT1-04 antibody; UGT1.4 antibody; UGT1A4 antibody; UGT1D antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human UGT1A4
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis. Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption.; Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
基因功能參考文獻：
1. Plant steroids competitively inhibited the UGT1A4-catalyzed trifluoperazine glucuronidation reaction suggesting potential for herb-drug interactions to occur. PMID: 27208893
2. Our findings highlight the influence of UGTT1A4 haplotypes on tamoxifen disposition in Asian breast cancer patients, while genetic variants in UGT2B7 and UGT2B15 appear to be of minor importance. PMID: 27098059
3. This study aimed to analyze the relationship of UGT2B7 and UGT1A4 polymorphisms with metabolism of valproic acid (VPA) and lamotrigine (LTG) in epileptic children. UGT1A4 L48V polymorphism was not related with the serum concentration of LTG (F=5.328, P=0.006). L48V polymorphism also showed effects on efficacy of LTG (chi2=17.397, P=0.001). PMID: 27795544
4. No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients. PMID: 28068583
5. The frequencies of two common UGT1A4 variants, *2 (P24T) and *3 (L48V), and their potential effects on serum concentrations of LTG. PMID: 25492569
6. Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children PMID: 26303110
7. This descriptive study examines correlations between concentrations of tamoxifen's glucuronide metabolites and genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 in 132 patients with estrogen receptor-positive breast cancer under treatment with tamoxifen PMID: 26176234
8. The association between the UGT1A4 promoter and coding region SNPs and the glucuronidation rates of Tam. PMID: 24917585
9. Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China PMID: 24820767
10. Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3. PMID: 24641623
11. the substrate specificity of UGT2B10, highlighting its preference for tertiary amines with higher affinities and clearance values than those of UGT1A4 and UGT1A3. PMID: 23611809
12. Present results could be helpful to improve the use of UGT1A4 drug substrates in order to adjust them to the ethnic background of a given population, specifically for Hispanics. PMID: 23277392
13. study to determine the allelic frequency of two most common defective alleles: UGT1A4*2 and UGT1A4*3 in a Jordanian population PMID: 22367373
14. Polymorphic glucuronidation of olanzapine by uridine diphosphate glucuronosyltransferase 1A4 (UGT1A4) was investigated retrospectively in patient samples PMID: 22713701
15. Study identified a large number of genetic variations, including 13 intronic, 39 promoter, as well as 14 exonic polymorphisms, with 10 that lead to amino-acid changes. PMID: 19890225
16. UGT1A4(P24T) and UGT1A4(L48V) on LTG glucuronidation may lead to interindividual variations in lamotrigine metabolism in vivo PMID: 22047493
17. The frequencies of the heterozygous alleles for L48V or P24T polymorphisms were 22.4% and 3.8%, respectively. L48V polymorphism was found to decrease the serum lamotrigine concentration in Turkish epilepsy patients on monotherapy or polytherapy. PMID: 21601426
18. kinetic studies with recombinant UGT1A4 using various substrates: dihydrotestosterone, trans-androsterone, tamoxifen, lamotrigine -- evidence for multiple substrate binding sites PMID: 20007295
19. Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. PMID: 15057901
20. hepatic clearance of trifluoperazine by UGT1A4 did not reach maximum levels until 18.9 years of age PMID: 17556526
21. AhR-mediated regulation of the human UGT1A4 gene by two xenobiotic response elements and a modulation by single nucleotide polymorphisms is demonstrated PMID: 18433817
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相關疾病：

Gilbert syndrome (GILBS); Crigler-Najjar syndrome 1 (CN1); Crigler-Najjar syndrome 2 (CN2)
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein.
蛋白家族：

UDP-glycosyltransferase family
組織特異性：

[Isoform 1]: Expressed in liver. Expressed in kidney, colon and small intestine. Not expressed in esophagus. Not expressed in skin.; [Isoform 2]: Expressed in liver, kidney, colon, esophagus and small intestine.
數據庫鏈接：

HGNC: 12536

OMIM: 143500

KEGG: hsa:54657

STRING: 9606.ENSP00000362508

UniGene: Hs.554822

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