UFM1 Antibody, FITC conjugated

說明書

中文名稱：

UFM1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA025560LC01HU
規格：

￥880
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UFM1 Polyclonal antibody
Uniprot No.：

P61960
基因名：

UFM1
別名：

BM 002 antibody; BM002 antibody; C13orf20 antibody; Chromosome 13 open reading frame 20 antibody; Ubiquitin fold modifier 1 antibody; Ubiquitin-fold modifier 1 antibody; UFM1 antibody; UFM1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ubiquitin-fold modifier 1 protein (11-63AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.
基因功能參考文獻：
1. UFM1 His 70 resembles UBA5 His336 and enters a negatively charged pocked on the other UFM1 molecule. PMID: 28360427
2. Ufmylation may participate in regulation of the vascular smooth muscle cells phenotypic switch and endothelial cell injury, which may help in the understanding of vascular remodeling. PMID: 29461087
3. These findings explicitly elucidate the role of UBA5 dimerization in UFM1 activation. PMID: 27653677
4. This study, focused on identifying the mutated gene in patients with hypomyelination with atrophy of the basal ganglia and cerebellum without TUBB4A mutations, revealed a homozygous 3-bp deletion in the UFM1 promoter area, which perfectly segregates with the disease. PMID: 28931644
5. Meta analysis identified a new gene, UFM1, that is associated with low von Willebrand factor levels. PMID: 26486471
6. in the absence of UFSP2, a deconjugating enzyme for UFM1, ectopic expression of both UFL1 and UFBP1, which serve as the E3-ligase complex for the UFM1-system, dramatically increases UFM1-conjugate formation at the endoplasmic reticulum. PMID: 27926783
7. data imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy PMID: 27545674
8. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy PMID: 27545681
9. results of an in vitro truncation assay suggest that Uba5 residues 57-363 comprise the minimal fragment required for the high-efficiency activation of Ufm1 PMID: 24915089
10. ASC1 is a target for ufmylation and that UFBP1 is an essential component for ASC1 ufmylation. PMID: 25219498
11. binding of ATP to Uba5 approximately Ufm1 thioester was required for efficient transfer of Ufm1 from Uba5 to Ufc1 via transthiolation. PMID: 24966333
12. Thus, UfSP2 proteins have protease- and Ufm1-independent functions in GPCR biogenesis. PMID: 24603482
13. the Ufm1 system plays a critical role in vesicle trafficking, and its inhibition may lead to protein overload in the ER and UPR activation. PMID: 23152784
14. A novel type of E3 ligase for the Ufm1 conjugation system. PMID: 20018847
15. The solution structure and dynamics of human Ufm1 (hsUfm1) by nuclear magnetic resonance spectroscopy was analysed. PMID: 16527251
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

UFM1 family
數據庫鏈接：

HGNC: 20597

OMIM: 610553

KEGG: hsa:51569

STRING: 9606.ENSP00000239878

UniGene: Hs.643655

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