UCHL3 Antibody
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中文名稱：UCHL3兔多克隆抗體
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貨號：CSB-PA025543GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：UCHL3
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別名：Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody; Ubiquitin thioesterase L3 antibody; Ubiquitin thiolesterase antibody; Ubiquitin thiolesterase L3 antibody; UCH L3 antibody; UCH-L3 antibody; UCHL3 antibody; UCHL3_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human UCHL3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
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基因功能參考文獻：
- The authors find that UCHL3 regulates COPS5-dependent deneddylation of Cullin1, which is an essential component of SCF(beta-TrCP) complex and associated with SCF(beta-TrCP) activities. The authors further demonstrate that UCHL3 upregulates the levels of SCF(beta-TrCP) substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity. PMID: 28583475
- Study demonstrated positive correlations between the level and activity of UCHL3 and sperm characteristics and function suggesting that UCHL3 may play a role in male infertility. PMID: 27780264
- Using a series of engineered protein substrates, which are similar in size yet differ in secondary structure, we demonstrate that thermal stability is a key factor that significantly affects UCH-L3 hydrolysis. PMID: 25369561
- UCH-L3 is a novel regulator of epithelial-mesenchymal transition and cell migration in prostate cancer cells. PMID: 25194810
- Data identified of UCHL3 as an essential deubiquitinase in adipogenesis. PMID: 22679485
- impaired UCH-L3 function may contribute to the accumulation of full length UBB(+1) in various pathologie PMID: 21762696
- 1.45 A resolution crystal structure of human UCH-L3 in complex with the inhibitor ubiquitin vinylmethylester, an inhibitor that forms a covalent adduct with the active site cysteine of ubiquitin-specific proteases PMID: 15531586
- Upregulation of UCH-L3 is associated with Uterine Cervical Neoplasms PMID: 16402389
- Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations. PMID: 19047059
- These results indicate that mono-Ub and Ub dimers may regulate the enzymatic functions of UCH-L1 and UCH-L3, respectively, in vivo. PMID: 19154770
- Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3 PMID: 19476499
- identification and the sequence-specific assignments for 186 out of the 218 UCH-L3 (230 less 12 prolines) backbone 15N and amide proton resonances PMID: 19636824
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亞細胞定位：Cytoplasm.
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蛋白家族：Peptidase C12 family
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組織特異性：Highly expressed in heart, skeletal muscle, and testis.
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數據庫鏈接：
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