UBE2T Antibody
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中文名稱：UBE2T兔多克隆抗體
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貨號：CSB-PA004361
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規格：￥1090
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圖片：
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Western Blot analysis of K562 cells using UBE2T Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：UBE2T
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別名：Cell proliferation inducing gene 50 protein antibody; Cell proliferation-inducing gene 50 protein antibody; HSPC150 antibody; HSPC150 protein similar to ubiquitin conjugating enzyme antibody; PIG50 antibody; Ube2t antibody; UBE2T_HUMAN antibody; Ubiquitin carrier protein T antibody; Ubiquitin conjugating enzyme antibody; ubiquitin conjugating enzyme E2 T antibody; Ubiquitin conjugating enzyme E2T antibody; Ubiquitin protein ligase T antibody; Ubiquitin-conjugating enzyme E2 T antibody; Ubiquitin-protein ligase T antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the Internal region of Human UBE2T.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
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基因功能參考文獻：
- Results show that UBE2T expression was increased in gastric tumors. Its suppression altered the expression of epithelial-mesenchymal transition factors and inhibited growth and colony formation, increased G2/M phase cell cycle arrest, and promoted apoptosis in gastric cancer cells. These findings provide evidence that UBE2T plays a critical role in gastric cancer. PMID: 28427240
- High UBE2T expression is associated with nasopharyngeal carcinoma. PMID: 26943030
- Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC and functions as an oncogene. The newly identified miR-543/UBE2T/p53 axis may represent a new potential therapeutic target for HCC intervention. PMID: 28935368
- report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro PMID: 28437106
- Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion. PMID: 27712593
- UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy. PMID: 27020591
- Identify critical roles of UBE2T in prostate cancer development and progression. PMID: 26308072
- we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene. PMID: 26085575
- UBE2T is the primary E2 of the FA pathway required for FANCD2 and FANCI activation. PMID: 26119737
- Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia PMID: 26046368
- hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway PMID: 21722982
- UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway. PMID: 16916645
- UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype. PMID: 18667844
- This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination. PMID: 19111657
- Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair. PMID: 19589784
- Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex. PMID: 19887602
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相關疾病：Fanconi anemia complementation group T (FANCT)
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亞細胞定位：Nucleus. Note=Accumulates to chromatin.
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蛋白家族：Ubiquitin-conjugating enzyme family
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