UBE2O Antibody

中文名稱：

UBE2O兔多克隆抗體
貨號：

CSB-PA866339LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: UBE2O antibody at 0.8µg/ml + A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 142 kDa
Observed band size: 142 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) UBE2O Polyclonal antibody
Uniprot No.：

Q9C0C9
基因名：

UBE2O
別名：

E2 230K antibody; EC=6.3.2.19 antibody; FLJ12878 antibody; KIAA1734 antibody; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme antibody; RP23 193A16.5 antibody; UBE2O antibody; UBE2O_HUMAN antibody; Ubiquitin carrier protein O antibody; Ubiquitin conjugating enzyme E2 O antibody; Ubiquitin conjugating enzyme E2 of 230 kDa antibody; ubiquitin conjugating enzyme E2O antibody; Ubiquitin protein ligase O antibody; Ubiquitin-conjugating enzyme E2 O antibody; Ubiquitin-conjugating enzyme E2 of 230 kDa antibody; Ubiquitin-conjugating enzyme E2-230K antibody; Ubiquitin-protein ligase O antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human (E3-independent) E2 ubiquitin-conjugating enzyme protein (10-277AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，UBE2O Antibody (CSB-PA866339LA01HU)，的標記方式是Non-conjugated。對于UBE2O Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA866339LB01HU	UBE2O Antibody, HRP conjugated	ELISA
FITC	CSB-PA866339LC01HU	UBE2O Antibody, FITC conjugated
Biotin	CSB-PA866339LD01HU	UBE2O Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.
基因功能參考文獻：
1. UBE2O is a self-contained quality control factor that comprises substrate recognition and ubiquitin transfer activities within a single protein to efficiently target orphans of multiprotein complexes for degradation. PMID: 28774922
2. UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. PMID: 28673317
3. UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathway. PMID: 28162974
4. UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1. PMID: 24703950
5. UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination. PMID: 23381138
6. monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis PMID: 23455153
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亞細胞定位：

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.
蛋白家族：

Ubiquitin-conjugating enzyme family
組織特異性：

Predominantly expressed in skeletal muscle and heart.
數(shù)據(jù)庫鏈接：

HGNC: 29554

OMIM: 617649

KEGG: hsa:63893

STRING: 9606.ENSP00000323687

UniGene: Hs.16130

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