UBE2G2 Antibody

中文名稱：

UBE2G2兔多克隆抗體
貨號：

CSB-PA025454LA01HU
規格：

￥440
圖片：
Western blot
All lanes: UBE2G2 antibody at 8µg/ml + K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 19, 16 kDa
Observed band size: 19 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA025454LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA025454LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UBE2G2 Polyclonal antibody
Uniprot No.：

P60604
基因名：

UBE2G2
別名：

Human ubiquitin conjugating enzyme G29 antibody; UB2G2_HUMAN antibody; UBC 7 antibody; UBC7 antibody; UBC7 homolog yeast antibody; UBE2G2 antibody; Ubiquitin carrier protein G2 antibody; Ubiquitin conjugating enzyme 7 antibody; Ubiquitin conjugating enzyme E2 G2 antibody; Ubiquitin conjugating enzyme E2G 2 (homologous to yeast UBC7) antibody; Ubiquitin conjugating enzyme E2G 2 (UBC7 homolog yeast) antibody; Ubiquitin conjugating enzyme E2G 2 (UBC7 homolog; yeast) antibody; Ubiquitin conjugating enzyme E2G 2 antibody; Ubiquitin conjugating enzyme G2 antibody; Ubiquitin protein ligase G2 antibody; Ubiquitin-conjugating enzyme E2 G2 antibody; Ubiquitin-protein ligase G2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ubiquitin-conjugating enzyme E2 G2 protein (1-165AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UBE2G2 Antibody (CSB-PA025454LA01HU)，的標記方式是Non-conjugated。對于UBE2G2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025454LB01HU	UBE2G2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025454LC01HU	UBE2G2 Antibody, FITC conjugated
Biotin	CSB-PA025454LD01HU	UBE2G2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.
基因功能參考文獻：
1. UBE2G2 was crucial for the degradation of various immunoreceptors. UBE2J2, on the other hand, counteracted US2-induced endoplasmic reticulum-associated protein degradation by downregulating TRC8 expression. PMID: 28743740
2. Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin chains. PMID: 27067047
3. The presence of the AUP1-Ube2g2 complex at LDs provides a direct molecular link between LDs and the cellular ubiquitination machinery. PMID: 21127063
4. Lys-48-linked polyubiquitin chains may be designed to bind certain proteins like Ube2g2 such that the terminal ubiquitin subunit carrying the reactive Lys-48 side chain can be positioned properly for chain elongation regardless of chain length. PMID: 21098018
5. Results report the solution structure and backbone dynamics of Ube2g2 solved by nuclear magnetic resonance spectroscopy. PMID: 20014027
6. Ubc7 mediates inositol 1,4,5-trisphosphate receptor ubiquitination and is a component of the endoplasmic reticulum-associated degradation pathway PMID: 12869571
7. interrupting a specific E2-E3 interaction can selectively inhibit endoplasmic reticulum -associated degradation PMID: 16407162
8. Structural comparison of human UBE2G2 with yeast Ubc7 indicated that the overall structures are similar except for the long loop region and the C-terminal helix. PMID: 16582478
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亞細胞定位：

Endoplasmic reticulum. Lipid droplet.
蛋白家族：

Ubiquitin-conjugating enzyme family
數據庫鏈接：

HGNC: 12483

OMIM: 603124

KEGG: hsa:7327

STRING: 9606.ENSP00000338348

UniGene: Hs.529420

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