UBASH3A Antibody
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中文名稱：UBASH3A兔多克隆抗體
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貨號：CSB-PA025427GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：UBASH3A
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別名：Cbl interacting protein 4 antibody; Cbl-interacting protein 4 antibody; CLIP4 antibody; STS 2 antibody; STS-2 antibody; Suppressor of T cell receptor signaling 2 antibody; Suppressor of T-cell receptor signaling 2 antibody; T cell ubiquitin ligand antibody; T cell ubiquitin ligand protein antibody; T-cell ubiquitin ligand 1 antibody; TULA antibody; TULA-1 antibody; UBASH3A antibody; ubiquitin associated and SH3 domain containing, A antibody; Ubiquitin-associated and SH3 domain-containing protein A antibody; UBS3A_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human UBASH3A-Specific
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
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基因功能參考文獻：
- UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. PMID: 28747736
- UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. PMID: 28607106
- A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. PMID: 25876712
- Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. PMID: 25843625
- these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. PMID: 25211447
- Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. PMID: 25075402
- Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. PMID: 23565265
- ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype PMID: 22776074
- The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
- Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases PMID: 15159412
- TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin PMID: 17382318
- TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors PMID: 17709377
- Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. PMID: 18006034
- TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk PMID: 18189269
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亞細胞定位：Cytoplasm. Nucleus.
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組織特異性：Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
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數據庫鏈接：
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