TUT1 Antibody
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中文名稱：TUT1兔多克隆抗體
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貨號：CSB-PA050066
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規格：￥1090
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其他：
產品詳情
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Uniprot No.：
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基因名：TUT1
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別名：alpha regulated poly(A) polymerase antibody; nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I antibody; nuclear speckle targeted PIPK1A regulated poly(A) polymerase antibody; PAP associated domain containing 2 antibody; PAPD2 antibody; poly(A) polymerase associated domain containing 2 antibody; RBM21 antibody; RNA binding motif protein 21 antibody; RNA-binding motif protein 21 antibody; RNA-binding protein 21 antibody; Speckle targeted PIP5K1A-regulated poly(A) polymerase antibody; Star-PAP antibody; STARPAP antibody; STPAP_HUMAN antibody; terminal uridylyl transferase 1; U6 snRNA specific antibody; TUT1 antibody; TUTase antibody; U6 snRNA specific terminal uridylyltransferase 1 antibody; U6 snRNA-specific terminal uridylyltransferase 1 antibody; U6 TUTase antibody; U6-TUTase antibody; URLC6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human TUTase.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
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基因功能參考文獻：
- Crystallographic and biochemical studies of TUT1 revealed the molecular mechanism underlying the specific oligo-uridylylation of the 3'-end of U6 snRNA by TUT1. PMID: 28589955
- Star-PAP possesses tumor-suppressing activity. PMID: 28151486
- Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. PMID: 28911096
- Star-PAP recognises a unique nucleotide motif on its target mRNA.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
- Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. PMID: 25142229
- Star-PAP controls E6 mRNA polyadenylation and expression and modulates wild-type p53 levels. PMID: 23416977
- The human TUT1 nucleotidyl transferase is a global regulator of microRNA abundance. PMID: 23874977
- Star-PAP and its regulatory molecules form a signaling nexus at the 3'-end of target mRNAs to control the expression of select group of genes including the ones involved in stress responses. (Review) PMID: 23306079
- PIPKIalpha, PI4,5P(2), and PKCdelta regulate Star-PAP control of BIK expression and induction of apoptosis. PMID: 22244330
- The data support a model where Star-PAP binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. PMID: 21102410
- PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, Star-PAP; the activity of Star-PAP can be specifically regulated by PtdIns4,5P2 PMID: 18288197
- These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages. PMID: 18305108
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亞細胞定位：Nucleus, nucleolus. Nucleus speckle.
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蛋白家族：DNA polymerase type-B-like family
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組織特異性：Widely expressed.
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數據庫鏈接：
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