TSEN15 Antibody

中文名稱：

TSEN15兔多克隆抗體
貨號：

CSB-PA840989LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA840989LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA840989LA01HU diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TSEN15 Polyclonal antibody
Uniprot No.：

Q8WW01
基因名：

TSEN15
別名：

TSEN15 antibody; C1orf19 antibody; SEN15 antibody; tRNA-splicing endonuclease subunit Sen15 antibody; SEN15 homolog antibody; HsSEN15 antibody; tRNA-intron endonuclease Sen15 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human tRNA-splicing endonuclease subunit Sen15 protein (1-171AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，TSEN15 Antibody (CSB-PA840989LA01HU)，的標記方式是Non-conjugated。對于TSEN15 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA840989LB01HU	TSEN15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA840989LC01HU	TSEN15 Antibody, FITC conjugated
Biotin	CSB-PA840989LD01HU	TSEN15 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
基因功能參考文獻：
1. results demonstrate that mutations in any known subunit of the TSEN complex can cause pontocerebellar hypoplasia and progressive microcephaly, emphasizing the importance of its function during brain development PMID: 27392077
2. A candidate SNP associated with the tRNA-splicing protein gene TSEN15 was independently associated with the risk of atrial fibrillation. PMID: 24944287
相關(guān)疾病：

Pontocerebellar hypoplasia 2F (PCH2F)
亞細胞定位：

Nucleus. Nucleus, nucleolus.
蛋白家族：

SEN15 family
組織特異性：

Widely expressed. Highly expressed in testis and uterus.
數(shù)據(jù)庫鏈接：

HGNC: 16791

OMIM: 608756

KEGG: hsa:116461

STRING: 9606.ENSP00000355299

UniGene: Hs.548197

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