TRPS1 Antibody
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中文名稱：TRPS1兔多克隆抗體
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貨號：CSB-PA025091GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：GC79 antibody; LGCR antibody; Transcriptional repressor GATA binding 1 antibody; Tricho rhino phalangeal syndrome I antibody; Tricho-rhino-phalangeal syndrome type I protein antibody; Trichorhinophalangeal syndrome I antibody; Trichorhinophalangeal syndrome I homolog antibody; TRPS 1 antibody; trpS1 antibody; TRPS1 gene antibody; TRPS1_HUMAN antibody; Zinc finger protein GC79 antibody; Zinc finger transcription factor TRPS 1 antibody; Zinc finger transcription factor Trps1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TRPS1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
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基因功能參考文獻：
- In Pseudohypoparathyroidism, mutations were found in PRKAR1A, PDE4D, TRPS1, and PTHLH. PMID: 29499646
- Two Pakistani families with sequence variants in GDF5 and TRPS1 causing brachydactyly type C and tricho-rhino-phalangeal syndrome type III are described. PMID: 29436063
- The results of this study indicated a prominent role of TRPS1 in subependymoma development. PMID: 28528424
- Results showed that TRPS1 along with GATA3 are distinctively overexpressed in breast cancer (BC) among all GATA family members and predict better survival in patients with BC. TRPS1 is then a distinctive biomarker and essential prognostic factor in BC. PMID: 28423734
- Downregulation of the TRPS1 protein, which is a transcriptional target of hsa-miR-26b-5p, was associated with radiation exposure. PMID: 28944451
- The first patient has a novel heterozygous two-base-pair deletion of nucleotides at 3198-3199 (c.3198-3199delAT) in the TRPS1 gene causing a translational frameshift and subsequent alternate stop codon. The second patient has a 3.08 million base-pair interstitial deletion at 8q23.3 (113,735,487-116,818,578), which includes the TRPS1 gene and CSMD3 PMID: 28256045
- the twins described by Fitzsimmons had heterozygous mutations in the SACS gene, the gene responsible for autosomal recessive spastic ataxia of Charlevoix Saguenay as well as a heterozygous mutation in the TRPS1, the gene responsible in Trichorhinophalangeal syndrome type 1A TBL1XR1 mutation was identified in the patient described in 2009 as contributing to his cognitive impairment and autistic features.. PMID: 27133561
- Clinically, three patients had TRPS I, two with multiple supernumerary teeth. The clinical impression was confirmed by a novel TRPS1 mutation. PMID: 27706911
- in this kindred support the previous genotype-phenotype results suggesting that patients with more pronounced facial characteristics and more severe shortening of hands and feet are more likely to have mutation in exon 6 of TRPS1 PMID: 28468609
- Down-regulation of TRPS1 by miR-373, acting as a transcriptional activator, promotes epithelial-mesenchymal transition (EMT) and metastasis by repressing FOXA1 transcription, expanding upon its previously reported role as a transcription repressor. PMID: 26969828
- TRPS1 gene was responsible for most of the TRPS phenotype PMID: 27826100
- Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation. PMID: 26183398
- Trps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. PMID: 26377811
- Single nucleotide polymorphisms in TRPS1 gene is associated with Coronary Artery Disease. PMID: 25328121
- Missense mutations are located exclusively in exon 6 and 7 of TRPS1 in patients with tricho-rhino-phalangeal syndrome. PMID: 25792522
- TRPS1 haploinsufficiency results in STAT3 and SOX9 mRNA expression in Trichorhinophalangeal syndrome. PMID: 25136899
- Trps1 is involved in non-anastomotic biliary structure pathogenesis following liver transplantation and negatively correlates with biliary epithelial cell epithelial-mesenchymal transition and biliary fibrosis in liver grafts. PMID: 25886207
- our study proposes that TRPS1 acts as a central hub in the control of cell cycle and proliferation during cancer development PMID: 25277197
- Identification of a novel missense mutation c.2726G>A (p.C909Y) of the TRPS1 gene in a family with trichorhinophalangeal syndrome type I. PMID: 25333908
- truncated protein from mutant allele may be stably expressed in patient's hair follicles PMID: 24909213
- we identified a mutation in the TRPS1 gene The same mutation was detected as a 10% mosaic mutation by Pyrosequencing in blood-derived DNA from his healthy mother. this is the first time that somatic mosaicism has been identified in TRPSI PMID: 23572024
- TRPS1 gene expressionis associated with different epithelial mesenchymal transformation markers in ERalpha-positive and ERalpha-negative breast cancers. PMID: 24934762
- Trps1 is required for odontoblast maturation by supporting expression of genes crucial for initiating the mineralization process. PMID: 25128529
- association between SNP within TRPS1 and BMD PMID: 24416236
- TRPS1 promotes angiogenesis and affects VEGFA expression in breast cancer. PMID: 24595984
- TRPS-1 is an independent prognostic marker in early-stage breast cancer and a new epithelial-to-mesenchymal transition marker that can distinguish patients with estrogen receptor-positive breast cancer who will respond longer to adjuvant endocrine therapy PMID: 23729783
- A role for Trps1 in the regulation of MDR1 expression in osteosarcoma. PMID: 24491996
- Identification of a new mutation in TRPS1 gene leading to tricho-rhino-phalangeal syndrome I in a Chinese patient PMID: 23293878
- we report the first familial balanced translocation [t(8;13)(q24.11;q21.31)] leading to trichorhinophalangeal syndrome I with a breakpoint 87 kb from the TRPS1 5' end. PMID: 23835950
- The increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. PMID: 23762846
- The strong expression of TRPS-1 may serve as a good prognostic marker in breast cancer. PMID: 24074613
- Mutations in the amino terminus of this transcription factor result in TRPS I syndrome. PMID: 22481165
- Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density PMID: 22306695
- TRPS1 codon 952 constitutes a mutational hot spot in trichorhinophalangeal syndrome type I and could be associated with intellectual disability. PMID: 22127049
- miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer. PMID: 21868360
- we found critical differences in TRPS-1 expression in primary breast cancer PMID: 21761348
- TRPS-1 was also found to be expressed in a high proportion of ER(-) ductal epithelial breast cancers PMID: 21761336
- TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer PMID: 21673316
- nonsense mutations result in premature stop codons in exon 4 or exon 5 and frame shifts from the point of deletion or two-to-one substitution also lead to premature stop codons downstream. PMID: 20394624
- Mutation in TRPS1 is associated with tricho-rhino-pharangeal syndrome. PMID: 20635356
- Trichorhinophalangeal syndrome:report on a family where the father & 3 children have a novel out-of-frame indel, the largest intragenic indel reported to date & comment on intrafamilial consistency of the resulting TRPS type I phenotype PMID: 20177376
- Review: Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene PMID: 11773701
- novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes PMID: 11950061
- homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros PMID: 12620233
- TRPS1 activity is regulated by RNF4 PMID: 12885770
- Our results suggest a role of TRPS1 in androgen regulation of prostate-specfici antigen gene expression PMID: 14680804
- TRPS-1 protein and gene were expressed in >90% of early- and late-stage breast cancer, including ductal carcinoma in situ and invasive ductal, lobular, and papillary carcinomas PMID: 16043716
- We show here that TRPS1 is SUMOylated at multiple sites, both in vivo and in vitro, through interaction with UBC9. Overexpression of wild-type UBC9 enhances TRPS1-mediated transcriptional repression. PMID: 17391059
- suggests a possible involvement of TRPS1 in oxidative stress, and possibly in apoptosis in androgen-independent DU145 prostate cancer cells PMID: 17467349
- study reports a family affected by a mild form of trichorhinophalangeal syndrome type I; mutation analysis showed a missense mutation (R952C) in exon 7 of the TRPS1 gene PMID: 17854380
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相關疾病：Tricho-rhino-phalangeal syndrome 1 (TRPS1); Tricho-rhino-phalangeal syndrome 2 (TRPS2); Tricho-rhino-phalangeal syndrome 3 (TRPS3)
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亞細胞定位：Nucleus.
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組織特異性：Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
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數據庫鏈接：
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