TRPM6 Antibody
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中文名稱：TRPM6兔多克隆抗體
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貨號：CSB-PA991562
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規格：￥1100
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圖片：
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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human jejunoileum tissue, Human ileum tissue, Primary antibody: CSB-PA991562(TRPM6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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其他：
產品詳情
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Uniprot No.：
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基因名：TRPM6
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別名：TRPM6 antibody; CHAK2Transient receptor potential cation channel subfamily M member 6 antibody; EC 2.7.11.1 antibody; Channel kinase 2 antibody; Melastatin-related TRP cation channel 6 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human TRPM6
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
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基因功能參考文獻：
- Results identified high expression of TRPM6 to be indicative of a prolonged overall survival in colorectal patients. Computational analysis suggest that TRPM6 may be targeted by hsalet7g and hsalet7f1. PMID: 30272358
- Spectrometric analysis identified phosphorylation sites in TRPM6 protein. PMID: 28220887
- Knockout of TRPM6 or inactivation of its kinase results in global changes in histone S/T phosphorylation and changes the transcription of hundreds of genes. PMID: 28784805
- Results found that the haplotype containing two common TRPM6 SNPs (rs3750425 and rs2274924) increases the risk for proton pump inhibitor-induced hypomagnesemia. PMID: 27926584
- TNF-alpha rescues the EGFR tyrosine kinase inhibitor-induced decrease in TRPM6 expression and Mg2+ influx mediated via the activation of an NF-kappaB signaling pathway. PMID: 27925186
- A homozygous frame-shift mutation in the TRPM6 gene is associated with Hereditary hypomagnesemia with secondary hypocalcemia. PMID: 26759217
- we showed that two serum magnesium associated loci, MUC1 and TRPM6, had significant effect modification with progestin use and insulin levels, respectively, in European Americans. PMID: 26058915
- TRPM6 mRNA and protein levels in atrial fibrillation group were elevated markedly in comparison with sinus rhythm group. PMID: 25796343
- Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg mal(re)absorption and hence systemic Mg balance. PMID: 24906182
- We conclude that the new TRPM6 missense mutations lead to dysregulated intestinal/renal Mg(2+) (re)absorption as a consequence of loss of TRPM6 channel function. PMID: 23942199
- TRPM6 kinase activity is linked to channel activity through a kinase-independent mechanism involving the dimerization motif binding to a pocket within the kinase domain. PMID: 24650431
- Two novel mutations in Chinese sisters with familial hypomagnesemia with secondary hypocalcemia were found: one frameshift mutation (c.1196delC) and one non-sense mutation (c.4577G>A). Both patients were compound heterozygotes for these mutations. PMID: 23689795
- PIP2 is required for TRPM6 channel function; hydrolysis of PIP2 by PLC-coupled hormones/agonists may constitute an important pathway for TRPM6 gating, and perhaps Mg2+ homeostasis. PMID: 22180838
- Case Report: Resolving basal ganglia calcification in hereditary hypomagnesemia with secondary hypocalcemia due to a novel TRPM6 gene mutation. PMID: 22982920
- Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy PMID: 22733750
- A novel mutation of TRPM6 gene is responsible for the development of familial hypommagnesaemia in Turkish children. PMID: 21669885
- Results suggest that TRPM6 expression is up-regulated by a PI3K/Akt/mTOR pathway . PMID: 21073857
- Loss-of-function mutations cause hypomagnesemia with secondary hypocalcemia. PMID: 20395377
- Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. PMID: 19937979
- Deficiency /mutations of TRPM6 causes hypomagnesemia with secondary hypocalcemia PMID: 12032568
- Individuals with TRPM6 mutations have abnormal renal magnesium excretion. Deficiency causes hypomagnesemia with secondary hypocalcemia. PMID: 12032570
- TRPM6 is specifically localized along the apical membrane of the renal distal convoluted tubule and the brush-border membrane of the small intestine and is specific for Mg2+ absoprtion. PMID: 14576148
- TRPM6 specifically interacted with its closest homolog, the Mg(2+)-permeable cation channel TRPM7, resulting in the assembly of functional TRPM6/TRPM7 complexes at the cell surface. PMID: 14976260
- In patients with primary hypomagnesaemia and secondary hypocalcaemia (HSH), a combined defect of intestinal magnesium absorption and renal magnesium conservation TRPM6 is the first component involved directly in epithelial magnesium reabsorption[review] PMID: 16075242
- data demonstrate that amino acid residues E1024, I1030 and D1031 are important for channel function and that subtle amino acid variation in the pore region accounts for TRPM6 permeation properties PMID: 17098283
- TRPM6 mutants are found in patients with a rare but severe hereditary disease called hypomagnesaemia with secondary hypocalcaemia --{REVIEW} PMID: 17217065
- This review discusses the importance of magnesium in vascular biology and implications in hypertension and highlights the transport systems, particularly TRPM6--REVIEW PMID: 18192217
- intracellular ATP regulates TRPM6 channel activity via its alpha-kinase domain independently of alpha-kinase activity PMID: 18490453
- diverse molecular regulation of TRPM6 by magnesiotropic hormones, intracellular factors and its fused alpha-kinase domain disclosed novel regulatory mechanisms of active magnesium reabsorption--REVIEW PMID: 18660673
- These findings clearly outline the activation of TRPM6 by EGF, a process fundamental to Mg2+ homeostasis. PMID: 19073827
- Our results provide suggestive evidence that two common non-synonymous TRPM6 coding region variants, Ile1393Val and Lys1584Glu polymorphisms, might confer susceptibility to type 2 diabetes in women with low magnesium intake PMID: 19149903
- REA operates as a negative feedback modulator of TRPM6 in the regulation of active Mg(2+) (re)absorption and provides new insight into the molecular mechanism of renal transepithelial Mg(2+) transport. PMID: 19329436
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相關疾病：Hypomagnesemia 1 (HOMG1)
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily; Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM6 sub-subfamily
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組織特異性：Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung
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