TRO Antibody, FITC conjugated

說明書

中文名稱：

TRO兔多克隆抗體, FITC偶聯
貨號：

CSB-PA025069LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRO Polyclonal antibody
Uniprot No.：

Q12816
基因名：

TRO
別名：

TRO antibody; KIAA1114 antibody; MAGED3 antibody; Trophinin antibody; MAGE-D3 antigen antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Trophinin protein (1-164AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
基因功能參考文獻：
1. Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study. PMID: 27035766
2. report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others PMID: 22201876
3. Trophinin induced apoptosis in endometrial epithelial cells through protein kinase C-delta. PMID: 21191175
4. infertile women with endometriosis or unexplained infertility had significantly weakened trophinin expression in the endometrium in the mid-luteal phase PMID: 12297480
5. HCG from the human embryo induces trophinin expression by maternal cells. Unique role of hCG and trophinin in human embryo implantation, including the pathogenesis of ectopic pregnancy. PMID: 14633596
6. Maged3 expression is restricted to the central nervous system where it was mostly detected in postmitotic neurons PMID: 15162511
7. Fluorescence photobleaching of GFP-trophinin expressed in COS-1 cells showed the stable association of trophinin with the nuclear envelope. PMID: 16288751
8. trophinin-mediated cell adhesion functions as a molecular switch for trophectoderm activation in human embryo implantation PMID: 17360433
9. results suggest that trophinin promotes colorectal cancer invasion through a mechanism involving HMGB1/RAGE PMID: 17487845
10. Trophinin functions as an adhesion molecule on the cell surface and as a molecular switch for trophoblast activation in the cytoplasm. PMID: 17495530
11. Confocal microscopy analysis of ectopically expressed magphinins revealed that magphinin-alpha and -beta localize in the cytoplasm, whereas magphinin-gamma lacking the peptide encoded by exon-3 is nuclear. PMID: 17559068
12. When magphinin-gamma was expressed in NIH3T3 cells, cells underwent G1 arrest. These results suggest that human magphinin-gamma inhibits cell cycle progression through nuclear activity. PMID: 17559068
13. These findings underscore the importance of TRO in tumorigenesis, and suggest that TRO may be a useful biomarker for cisplatin sensitivity and invasive potential. PMID: 17597582
14. results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst PMID: 18078818
15. Overexpression of trophinin leads to a more invasive phenotype and metastatic potential in human gallbladder cancer transfected into nude mice. PMID: 18846386
16. TROPHONIN (TRO) is among the genes most downregulated by RAS. TRO expression is higher in cisplatin-sensitive cancer cell lines and positively correlates with prognoses in ovarian cancers. PMID: 17597582
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組織特異性：

Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week
數據庫鏈接：

HGNC: 12326

OMIM: 300132

KEGG: hsa:7216

STRING: 9606.ENSP00000173898

UniGene: Hs.633653

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