TRIM32 Antibody
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中文名稱：TRIM32兔多克隆抗體
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貨號：CSB-PA024469GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：72 kda Tat interacting Protein antibody; 72 kDa Tat-interacting protein antibody; BBS11 antibody; E3 ubiquitin-protein ligase TRIM32 antibody; HT2A antibody; LGMD2H antibody; Limb girdle muscular dystrophy 2H (autosomal recessive) antibody; Limb girdle muscular dystrophy 2H antibody; Muscular dystrophy Hutterite type antibody; TAT interactive protein 72KD antibody; TATIP antibody; TRI32_HUMAN antibody; Trim32 antibody; Tripartite Motif Containing Protein 32 antibody; Tripartite motif-containing protein 32 antibody; Zinc finger protein HT2A antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TRIM32
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha. Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation.; (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.
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基因功能參考文獻：
- TRIM32 as a crucial positive regulator of Herpes Simplex Virus type 1 (HSV-1) induced IFN-beta production in corneal epithelial cells, and it played a predominant role in clearing HSV-1 from the cornea. PMID: 28954259
- HSP70-TRIM32 complex is biochemically distinct from the previously characterized 14-3-3-TRIM32 phospho-complex. PMID: 28052117
- Data suggest that, in cardiomyocytes, TRIM32 attenuates activation of SRF signaling and hypertrophy due to dysbindin; TRIM24 promotes these effects. TRIM32 promotes dysbindin degradation; TRIM24 protects dysbindin from degradation. (TRIM = tripartite motif-containing protein; SRF = serum response factor) PMID: 28465353
- Duchenne muscular dystrophy muscles showed a selective up-regulation of the ubiquitin ligase tripartite motif-containing protein 32 (TRIM32). The induction of TRIM32 was due to a transcriptional effect and it correlated with disease severity. PMID: 27295345
- we provide a detailed characterization of the TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic activity PMID: 27154206
- that TRIM32 plays a protective role in aortic banding-induced pathological cardiac remodelling by blocking Akt-dependent signalling PMID: 26884348
- these findings suggest that TRIM32 might play important roles in the hepatocarcinogenesis. PMID: 27573002
- results show a novel molecular cascade involving miR-155 and TRIM32 leading to HIV-1 Tat-induced attenuated proliferation of neural precursor cells; study also uncovered an unidentified role for miR-155 in modulating human neural stem cell proliferation, helping in better understanding of neural precursor cells and diseased brain PMID: 26586575
- Results suggest that Salmonella effector SseK3 binding to host tripartite motif-containing 32 protein (TRIM32) in the inhibition of nuclear factor kappa B (NF-kappaB) activation: [SseK3] PMID: 26394407
- TRIM32 represents a model of intrinsic immunity, in which a host protein directly senses and counters viral infection in a species specific fashion by directly limiting viral replication PMID: 26057645
- Data indicate that variants in tripartite motif-containing 32 protein (TRIM32) in two patients presenting nonspecific limb-girdle muscular dystrophy type 2H (LGMD2H) were identified by using high-throughput variants screening techniques. PMID: 25351777
- TRIM32, an E3 ubiquitin ligase, promotes HIV reactivation from latency by directly modifying IkappaBalpha PMID: 25873391
- Identification of TRIM32 as a novel p53 target and as a novel negative regulator for p53. PMID: 25146927
- Trim32 is a positive regulator of ACD that acts against MYCN and should be considered as a tumor-suppressor candidate PMID: 25100564
- Deletions near the 3' terminus of ASTN2, a subset of these deletions also includes TRIM32, are significantly enriched in neurodevelopmental disorder subjects. PMID: 24381304
- BBS11 promotes accumulation of NPHP7, changing the properties of NPHP7. TRIM32 Modulates the Transcriptional Activities of Glis2 PMID: 24500717
- a novel connection between ubiquitylation and phosphorylation pathways, which could modulate a variety of cell events by stimulating the formation of the 14-3-3-TRIM32 signaling complex. PMID: 23444366
- TRIM32 assembles polyubiquitin chains as a Ubc5-linked thioester intermediate. PMID: 23408431
- TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination PMID: 22745133
- These findings suggest that TRIM32 functions as one of the coactivators for RARalpha-mediated transcription in acute promyelogenous leukemia cells. PMID: 22182411
- promotes neural differentiation through retinoic acid receptor-mediated transcription PMID: 21984809
- Malin is related to TRIM32 at both the phylogenetic and functional level. PMID: 21798009
- TRIM32 sensitizes TNFalpha-induced apoptosis by antagonizing XIAP PMID: 21628460
- It is likely that C-terminal mutations in TRIM32 affect the ability of muscle proteins to be degraded by the ubiquitin-proteasome pathway.[review] PMID: 21496629
- As CCL20 is activated by Th17 cytokines, the upregulation of CCL20 production by Trim32 provides a positive feedback loop of CCL20 and Th17 activation in the self-perpetuating cycle of psoriasis PMID: 20054338
- limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene PMID: 11822024
- TRIM32 mutation found in the sarcotubular myopathy patients is identical to the causative mutation for LGMD2H (D487N) PMID: 15786463
- Mutation analysis of TRIM32 shows it is a Bardet-Biedl syndrome gene. PMID: 16606853
- by controlling Piasy stability, Trim32 regulates UVB-induced keratinocyte apoptosis through induction of NFkappaB PMID: 16816390
- The mutations here reported may cause muscular dystrophy by affecting the interaction properties of TRIM32. PMID: 17994549
- Together with two recently reported mutations, this novel mutation confirms that integrity of the C-terminal domain of TRIM32 is necessary for muscle maintenance. PMID: 19303295
- TRIM32 is a widely expressed ubiquitin ligase and binds and ubiquitinates dysbindin. PMID: 19349376
- Intragenic deletion of TRIM32 in compound heterozygotes with sarcotubular myopathy/LGMD2H PMID: 19492423
- The interplay between Trim32 and Pias3 is positively regulated by nitric oxide. PMID: 17987106
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相關疾病：Limb-girdle muscular dystrophy 2H (LGMD2H); Bardet-Biedl syndrome 11 (BBS11)
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亞細胞定位：Cytoplasm.
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蛋白家族：TRIM/RBCC family
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組織特異性：Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle.
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