TRAC Antibody
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中文名稱：TRAC兔多克隆抗體
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貨號：CSB-PA024144LA01HU
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規(guī)格：￥440
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：
CUSABIO's product CSB-PA024144LA01HU is a polyclonal antibody raised in rabbits against the recombinant human TRAC protein (1-140AA). It occurs as an unconjugated IgG. Its purity is greater than 95% using protein G purified. It only shows reactivity with human TRAC protein, a subunit chain of the T-cell receptor (TCR) that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. This TRAC antibody is suitable for the detection of TRAC protein in ELISA analysis.
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TRAC Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：TRAC antibody; TCRA antibody; T cell receptor alpha constant antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human T cell receptor alpha constant protein (1-140AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，TRAC Antibody (CSB-PA024144LA01HU)，的標(biāo)記方式是Non-conjugated。對于TRAC Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
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相關(guān)疾病：Immunodeficiency 7 (IMD7)
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亞細胞定位：Cell membrane.
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數(shù)據(jù)庫鏈接：
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