TPTE2 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TPTE2 Polyclonal antibody
Uniprot No.：

Q6XPS3
基因名：

TPTE2
別名：

TPTE2; TPIP; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Lipid phosphatase TPIP; TPTE and PTEN homologous inositol lipid phosphatase
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 protein (167-411AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.; Shows no phosphoinositide phosphatase activity.
基因功能參考文獻：
1. The role of TPTE2 in gallbladder cancer cells PMID: 25676706
2. TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP and Dr-VSP, have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well. PMID: 22896666
3. findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex PMID: 22311048
4. the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells PMID: 22164291
亞細胞定位：

[Isoform 3]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 4]: Cytoplasm.
組織特異性：

Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
數據庫鏈接：

HGNC: 17299

OMIM: 606791

KEGG: hsa:93492

STRING: 9606.ENSP00000372437

UniGene: Hs.377488

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