TP53AIP1 Antibody
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中文名稱：TP53AIP1兔多克隆抗體
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貨號：CSB-PA884624DSR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA884624DSR2HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA884624DSR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TP53AIP1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：p53 regulated apoptosis inducing protein 1 antibody; p53-regulated apoptosis-inducing protein 1 antibody; P53AIP 1 antibody; p53AIP1 antibody; TP53AIP 1 antibody; TP53AIP1 antibody; TPIP1_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human p53-regulated apoptosis-inducing protein 1 protein (1-108AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May play an important role in mediating p53/TP53-dependent apoptosis.
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基因功能參考文獻：
- results show that constitutional truncating TP53AIP1 mutations predispose to CMM in the French population PMID: 29359367
- Data indicate that p53-regulated apoptosis-inducing protein 1 (p53AIP1) inhibits the proliferation of PC-3M cells, arrests cell cycle at S/G2-M phase, decreases the abilities of invasion and migration and promotes cell apoptosis. PMID: 25108434
- These studies indicate the critical role of p53AIP1 under DNA damaging stresses for cell fate determination in rheumatoid arthritis-fibroblast-like synovioctes containing the p53R248Q mutation. PMID: 24316591
- Apak competes with p53 for binding to inhibit p53AIP1 expression. PMID: 22334068
- large sample size of the combined cohort rejects a high-risk effect greater than 2.2 and indicates a limited role of TP53AIP1 in prostate cancer predisposition PMID: 22457820
- p53AIP1 regulates the mitochondrial apoptotic pathway. PMID: 12019168
- The expression of Ki67 and p53 in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia. PMID: 14707453
- expression of the p53 mutant, R248Q, in liver cancer cells may enhance their drug resistance and upregulation of P-glycoprotein activity may contribute to this protective effect. PMID: 15004724
- Roscovitine induced up-regulation of p53AIP1 protein and the depolarization of mitochondrial potential. PMID: 15657359
- p53AIP1 gene is important for non-small cell lung cancer progression and may be a possible prognostic marker PMID: 17851056
- Insufficient expression of p53AIP1 may play a role in gastric carcinogenesis in patients infected with H. pylori infection. PMID: 18277906
- Data suggest that the combination of p53AIP1 and survivin gene expression may be a powerful tool to stratify subgroups with better or worse prognosis from the variable non-small cell lung cancer population. PMID: 19228369
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亞細胞定位：Mitochondrion.
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組織特異性：Only found to be expressed in thymus.
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數據庫鏈接：
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