TNS4 Antibody, HRP conjugated
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中文名稱：TNS4兔多克隆抗體, HRP偶聯
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貨號：CSB-PA810319LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TNS4 Polyclonal antibody
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Uniprot No.：
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基因名：TNS4
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別名：C terminal tensin like antibody; C terminal tensin like protein antibody; C-terminal tensin-like protein antibody; CTEN antibody; FLJ14950 antibody; PP14434 antibody; TENS4_HUMAN antibody; Tensin 4 antibody; Tensin-4 antibody; Tns4 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Tensin-4 protein (20-231AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. May promote apoptosis, via its cleavage by caspase-3.
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基因功能參考文獻：
- CTEN activated the expression of TGFB1, thereby prompting epithelial-mesenchymal transition in lung adenocarcinoma cancer cells. PMID: 29985912
- Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1. PMID: 29102927
- Cten-Snail signaling pathway contributes to cell motility in colorectal cancer (CRC), mediated by the stabilization of Snail protein. PMID: 28691764
- Conclude that in colorectal cancer, Cten is upregulated by EGFR and Kras but downregulated by STAT3. PMID: 26852686
- Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma PMID: 26035355
- Cten expression mediates invasion of human lung cancer cells and is upregulated by epidermal growth factor via STAT3. PMID: 25439778
- Findings indicate that induction of Cten protein expression is a relatively early event in melanoma progression, and that Cten has the potential to serve as a prognostic marker for primary melanoma patients. PMID: 24244691
- Up-regulated cten modulates cell migration induced by FGF2. PMID: 23625726
- Significant correlation between MET and TNS4 expression in human colon carcinoma and ovarian carcinoma suggests TNS4 plays a critical role in MET stability in cancer. PMID: 24814316
- CTEN regulates EGFR protein levels through a posttranslational mechanism. PMID: 23774213
- Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. PMID: 23500447
- Show an oncogenic role for CTEN in pancreatic cancer through promotion of colony formation and cell motility. PMID: 22750970
- conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility PMID: 21698197
- Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis. PMID: 21339732
- CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma. PMID: 20390342
- Increased cten mRNA expression was correlated with tumor progression in lung cancers PMID: 12711115
- Cten/GAPDH mRNA expression was correlated with evidence of tumor progression in thymoma. PMID: 15001839
- These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. PMID: 17190795
- Expression of CTEN correlates with high tumor grade and metastasis to lymph nodes, suggesting that CTEN may contribute to tumor invasiveness. PMID: 17765673
- TNS4 mRNA expression was significantly higher in gastric cancer. PMID: 18612693
- Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers. PMID: 19487278
- CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients. PMID: 19725034
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亞細胞定位：Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
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組織特異性：Prostate and placenta. Down regulated in prostate cancer.
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數據庫鏈接：
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