TNRC6A Antibody, Biotin conjugated
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中文名稱：TNRC6A兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA839859LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TNRC6A Polyclonal antibody
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Uniprot No.：
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基因名：TNRC6A
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別名：CAG repeat protein 26 antibody; CAGH26 antibody; DKFZp666E117 antibody; EDIE antibody; EMSY interactor protein antibody; FLJ22043 antibody; Glycine tryptophan protein of 182 kDa antibody; Glycine-tryptophan protein of 182 kDa antibody; GW1 antibody; GW182 antibody; GW182 autoantigen antibody; Hypothetical protein DKFZp566M143 antibody; KIAA1460 antibody; MGC75384 antibody; OTTHUMP00000122485 antibody; OTTHUMP00000195164 antibody; OTTHUMP00000195165 antibody; Protein GW1 antibody; TNR6A_HUMAN antibody; TNRC 6A antibody; TNRC6 antibody; Tnrc6a antibody; Trinucleotide repeat containing 6A antibody; Trinucleotide repeat containing gene 6A protein antibody; Trinucleotide repeat-containing gene 6A protein antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Trinucleotide repeat-containing gene 6A protein (1-161AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.
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基因功能參考文獻：
- that the interactions observed between TNRC6A and importin-alpha are conserved between mouse and human complexes. Our results highlight the ability of monopartite cNLS sequences to maximise contacts at the importin-alpha major binding site, as well as regions outside the main binding cavities PMID: 28837617
- The results suggest that overexpressed Dcp1a and GW182 can form different cytoplasmic aggregates and play distinct biological roles in the miRNA pathway. PMID: 28488892
- The results indicate that TNRC6A subcellular localization is substantially controlled by the interaction with Argonaute proteins. PMID: 26446993
- TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. PMID: 24778252
- we have identified a new function of GW182 in protecting mature miRNA from being degraded by interacting with Argonaute (AGO) proteins PMID: 23090477
- HSP90 and GW182 are important factors in the pathomechanism of alcohol-induced augmentation of HCV replication. PMID: 22898980
- GW182 plays a critical role in miRNA-mediated gene silencing. (Review) PMID: 23224966
- GW182 proteins function as scaffold proteins for the assembly of the multiprotein complex that silences miRNA targets. (Review) PMID: 23224969
- 28.6% of patients containing autoantibodies to the trinucleotide repeat region of the TNRC6A were shown to have a single nucleotide polymorphism at c.344C>A in the CAG/CCA/G-rich region of TNRC6A. PMID: 23224974
- Sinse Argonaute and GW182 are the core proteins of the RNA-silencing complex (RISC), it seems appropriate to suggest that the RISC is the main target of human autoantibodies. (Review) PMID: 23224975
- Analysis of the results suggested that TNRC6A plays an important role in navigating Argonaute protein into the nucleus to lead miRNA-mediated gene silencing. PMID: 23150874
- Mammalian GW proteins have distinctive functions in the miRNA pathway, with GW220/TNGW1 being essential for aggregation and formation of GW/P bodies that sequester and stabilize translationally repressed target mRNA. PMID: 22891262
- Data demonstrate that in human and Drosophila melanogaster cells, the critical repressive features of both the N-terminal and C-terminal effector domains of GW182 proteins are Gly/Ser/Thr-Trp (G/S/TW) or Trp-Gly/Ser/Thr (WG/S/T) motifs. PMID: 21984184
- Data suggest that GW182 serves as both a platform that recruits deadenylases and as a deadenylase coactivator that facilitates the removal of the poly(A) tail by CCR4-NOT. PMID: 21984185
- Alanine substitution showed that GW/WG motifs in Delta12 (Delta12a, amino acids 896-1045) were important for the silencing activity of GW182. PMID: 21131274
- GW ribonucleoprotein complex is involved in the posttranscriptional regulation of gene expression PMID: 11950943
- gene knockdown of GW182 led to the disappearance of GW bodies demonstrating that GW182 is a critical component of GW bodies PMID: 15494374
- data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing PMID: 16284622
- results support a functional link between GW182 and the ability of a microRNA to repress expression of a target mRNA PMID: 16284623
- A novel 210-kDa isoform of human GW182, provisionally named trinucleotide GW1 (TNGW1)was reported.TNGW1 was expressed independently of GW182 and was present in human testis and various human cancer cells. PMID: 19056672
- Our findings indicate that TNRC6A, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768
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亞細胞定位：Cytoplasm, P-body.
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蛋白家族：GW182 family
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組織特異性：Ubiquitous.
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