TNFRSF6B Antibody

說明書

中文名稱：

TNFRSF6B兔多克隆抗體
貨號：

CSB-PA002089
規格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using DcR3 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O95407
基因名：

TNFRSF6B
別名：

DcR3 antibody; Decoy receptor 3 antibody; Decoy receptor for Fas ligand antibody; DJ583P15.1.1 antibody; M68 antibody; M68E antibody; OTTHUMP00000031583 antibody; TNF6B_HUMAN antibody; TNFRSF6B antibody; TR6 antibody; Tumor necrosis factor receptor superfamily member 6B antibody; Tumor necrosis factor receptor superfamily member 6b decoy antibody; UNQ186/PRO212 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human DcR3.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
基因功能參考文獻：
1. The combination of decoy receptor 3, soluble urokinase type plasminogen activator receptor, and procalcitonin improved the sensitivity and specificity of diagnosis of sepsis, suggesting that use of the combination of three indexes enhanced the efficiency of sepsis diagnosis. PMID: 29760745
2. Compared with the control, miR-340 was significantly lower in the serum of hepatocellular carcinoma patients (p<0.01). miR-340 was lower in HCC tissues than in adjacent; however, DcR3, TGF-beta1 and Smad2 were higher. PMID: 29311025
3. DcR3 treatment caused HepG2 cell cytoskeleton remodeling, inhibited E-cadherin expression, and promoted cell migration. PMID: 28560426
4. DcR3 gene polymorphisms are associated with sporadic breast infiltrating ductal carcinoma risk in Northeast Chinese females PMID: 27517320
5. Study found that both transcriptional expression and post-transcriptional DcR3 expression DcR3 expression were significantly up-regulated in colorectal cancer (CRC) tissues. DcR3 was found to be playing a critical role in CRC proliferation and migration in vitro and in tumorigenesis and metastasis in vivo. PMID: 27764793
6. Higher plasma DcR3 level was related to better coronary collateral circulation (CCC) formation and displayed potent predictive power for CCC status in patients with coronary artery disease. PMID: 28942284
7. High serum DcR3 levels are associated with disease severity in nonatopic asthma patients. PMID: 26911723
8. Results show that DcR3 engages TNF ligands: FasL, LIGHT, and TL1A in a structurally similar fashion and its promiscuity is due to recognition of backbone atoms and invariant side chains. PMID: 27806260
9. when idiopathic pulmonary fibrosis cells interact with collagen matrix, aberrantly activated Akt increases DcR3 expression via GSK-3beta-NFATc1 and protects IPF cells from the FasL-dependent apoptotic pathway. PMID: 27218286
10. Coexpression of TNFRSF6B and PCDHGA3 was observed immunohistochemically in FL18 cells, suggesting potential cooperation in tumor cell maintenance. PMID: 27748813
11. Loss of DcR3 impaired the growth and invasive property of HCC cell line of HepG2. PMID: 27779171
12. Overexpression of DcR3 was significantly related to the risk of female reproductive cancers (OR=10.69, 95% CI: 6.33-18.05), TNM stage (OR=5.51, 95% CI: 2.83-10.71), differentiation (OR=4.16, 95% CI: 2.28-7.60), lymph node metastasis (OR=5.89, 95% CI: 3.16-10.9), age (OR=0.85, 95% CI: 0.51-1.44), and overall survival time (OR=1.84, 95% CI: 0.58-5.83). PMID: 27246752
13. The serum level of DcR3 may be a useful marker for disease activity in ANCA-associated renal vasculitis. PMID: 27251675
14. The sDcR3 levels in patients with HIV-1 subtype B were significantly higher than those in patients infected with subtype CRF01_AE. HIV-1 subtype B and slow disease progression were associated with higher levels of sDcR3. PMID: 26062966
15. DcR3 inhibits influenza a virus-induced JNK and ERK activation in human macrophages PMID: 25940317
16. Decoy receptor 3 (DcR3) expression in kidneys has been shown to predict progression of chronic kidney disease. PMID: 26335204
17. Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts PMID: 26238767
18. tumour markers DcR3 and growth/differentiation factor (GDF)15 from 100 mul human serum, were quantified. PMID: 25823874
19. Serum DcR3 expression in primary Sjogren's syndrome (pSS) patients was significantly higher than healthy controls. DcR3 expression in salivary glands of pSS patients was significantly higher than healthy controls. PMID: 25564309
20. study has defined the increased serum and SF samples levels of TL1A and DcR3 in patients with rheumatoid arthritis (RA); findings support the hypothesis that TL1A and DcR3 may contribute to the pathogenesis of RA PMID: 25647275
21. decoy receptor 3 and geriatric nutrition have a role in mortality in chronic hemodialysis patients PMID: 25323840
22. Higher DcR3 expression was related to the status of invasion, lymph node metastasis and recurrence in bladder urothelial carcinoma. PMID: 25422191
23. HER2 overexpression is not an independent prognostic marker of colorectal cancer, but DcR3 overexpression is highly correlated with lymph node metastasis and poor overall survival PMID: 24764685
24. The overexpression of DcR3 might play a crucial role in the tumorigenesis, differentiation, and proliferation of glioma. PMID: 24741354
25. Overexpression of TNFRSF6B is associated with hepatocellular carcinoma. PMID: 24998573
26. A case-control study of esophageal squamous-cell carcinoma (ESCC)found that the DcR3 SNPs were not associated with the risk of ESCC. PMID: 24786982
27. Inhibition of B cell functions by DcR3 may partially explain the negative correlation between DcR3 level and disease activity in rheumatoid arthritis patients. PMID: 25084482
28. High serum DcR3 expression correlated with lymph node metastases in in pancreatic head carcinoma PMID: 24597666
29. DcR3 is a key driver of tumor cell dissemination. PMID: 24107265
30. DcR3 may play an etiologic role in systemic lupus erythematosus through either elevated serum levels of wild-type DcR3 or normal levels of gain-of-function DcR3 proteins that increase lymphocyte proliferation. PMID: 23729807
31. Rare missense mutations in TNFRSF6B have a role in the pathogenesis of some cases of IBD. PMID: 23965943
32. DCR3 is overexpressed in breast cancer and in vascular endothelial cells and tumor cells in the lymph nodes, revealing a possible link with lymphangiogenesis. PMID: 24612949
33. Silencing of decoy receptor 3 (DcR3) expression by siRNA in pancreatic carcinoma cells induces Fas ligand-mediated apoptosis in vitro and in vivo. PMID: 23846297
34. Our results implied the therapeutic potential of silencing DcR3 expression by RNAi in colon cancer. PMID: 24101127
35. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH. PMID: 23817777
36. Serum DcR3 level may be useful for detecting Hepatitis Be Antigen (-) Chronic hepatitis B in the active stage, which requires medical treatment. PMID: 23925044
37. DcR3 might regulate the gene expression of various key molecules in rheumatoid arthritis fibroblast-like synoviocytes by binding to TL1A. PMID: 23912906
38. Data suggest DcR3 expression in DSV-PTC (diffuse sclerosing variant of papillary thyroid carcinoma) tumor cells promotes polarized macrophage differentiation toward the M2 phenotype and thus has role in recruitment of tumor-associated macrophages. PMID: 23186064
39. high expression of TNFRSF6B is a novel biomarker for predicting the progression of chronic kidney disease PMID: 23449012
40. DcR3 expression was associated with other prognostic factors including survivin, reduced remission rates, and shorter event-free survival. PMID: 23652586
41. novel regulatory mechanisms of DcR3 expression in psoriasis, particularly in keratinocytes and endothelial cells, provides new insight into the pathogenesis of psoriasis PMID: 23707413
42. DcR3 and ERK1/2 play a vital role in the development of gastric cancer, and they may be new markers for indicating the efficiency of gastric cancer treatment in the future. PMID: 22672288
43. Higher DcR3 levels strongly correlate with inflammation and independently predict cardiovascular and all-cause mortality in CKD patients on hemodialysis. PMID: 22626963
44. High expression and amplification of the DcR3 gene is associated with pancreatic carcinoma. PMID: 22524850
45. These results imply that DcR3 may regulate B cell activation by suppressing the activation of NF-kappaB. PMID: 22581854
46. The increased synovial inflammatory cells infiltration in rheumatoid arthritis and ankylosing spondylitis was associated with the elevated DCR3 expression. PMID: 22325083
47. Significantly enhanced tumor growth and spreading are observed in DcR3-transgenic mice; DcR3-transfectant cells grow faster and result in infiltration by tumor-associated macrophages. PMID: 22287720
48. The expression of DcR3 in vascular endothelial cells during the early phases of Kaposi's sarcoma-associated herpesvirus infection ensures the successful establishment and maintenance of the viral infection. PMID: 21293109
49. DcR3-Fc inhibits the proliferation induced by TNFalpha or IL-1beta in rheumatoid arthritis. PMID: 21537832
50. EMS1 expression was positively related to DcR3, which might play an important role in the carcinogenesis and development of laryngeal carcinoma. PMID: 21395182
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亞細胞定位：

Secreted.
組織特異性：

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
數據庫鏈接：

HGNC: 11921

OMIM: 603361

KEGG: hsa:8771

STRING: 9606.ENSP00000359013

UniGene: Hs.434878

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