TNFAIP6 Antibody

說明書

中文名稱：

TNFAIP6兔多克隆抗體
貨號：

CSB-PA023959GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P98066
基因名：

TNFAIP6
別名：

Hyaluronate binding protein antibody; Hyaluronate-binding protein antibody; TNF alpha induced protein 6 antibody; TNF alpha-induced protein 6 antibody; TNF stimulated gene 6 protein antibody; TNF-stimulated gene 6 protein antibody; TNFAIP 6 antibody; Tnfaip6 antibody; TSG 6 antibody; TSG-6 antibody; TSG6_HUMAN antibody; Tumor necrosis factor alpha induced protein 6 antibody; Tumor necrosis factor alpha inducible protein 6 antibody; Tumor necrosis factor alpha-induced protein 6 antibody; Tumor necrosis factor inducible gene 6 protein antibody; Tumor necrosis factor stimulated gene 6 protein antibody; Tumor necrosis factor-inducible gene 6 protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TNFAIP6
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
基因功能參考文獻：
1. TSG-6 up-regulation counteracts the progression of atherosclerosis. (Review) PMID: 29401724
2. TSG-6 from MSCs attenuated severe burn-induced excessive inflammation via inhibiting activation of P38 and JNK signaling. PMID: 27444207
3. TSG-6 secreted by human mesenchymal stem cells suppresses inflammatory reactions through p38 and ERK in the mitogen-activated protein kinase pathway PMID: 28247086
4. This review will focus on the potential of mesenchymal stem/stromal cells for treatment of fibrotic diseases, with emphasis on the role of TSG-6 as a mediator of anti-inflammatory effects PMID: 26807758
5. abnormally elevated in both the plasma and aortic wall of patients with abdominal aortic aneurysms PMID: 29180197
6. Single nucleotide polymorphism in TNFAIP6 gene is associated with Systemic lupus erythematosus. PMID: 28246883
7. TNFAIP6 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
8. Data show that TNF-stimulated gene-6 (TSG-6) interacts with chemokines through their glycosaminoglycans (GAGs)-binding sites and inhibits their binding to GAGs and endothelial cell surfaces. PMID: 27044744
9. Data postulate that the molecular cross-linking enhanced by the multiple binding modes of the Link module might be critical for remodeling the ECM during inflammation/ovulation and might contribute to other functions of TSG-6. PMID: 26685054
10. the well characterized hyaluronan-binding site in the TSG-6 Link module is not used for recognition during transfer of HCs onto HA. PMID: 26468290
11. TSG-6 exhibited anti-inflammatory effects during the wound healing process and cicatrization and significantly diminished hypertrophic scar formation in a rabbit ear model PMID: 25661977
12. results suggest that systemic administration of hASC or TSG-6 may be novel approaches to reverse CS-induced myelosuppression. PMID: 25329668
13. TSG-6 activity in tissues, was examined. PMID: 25325979
14. TSG-6 expression by hMSCs was induced 12 h after oropharyngeal delivery to LPS-exposed lungs. Knockdown of TSG-6 expression in hMSCs by RNA interference abrogated most of their anti-inflammatory effects. PMID: 21569482
15. Heavy chain transfer by tumor necrosis factor-stimulated gene 6 to the bikunin proteoglycan. PMID: 25561734
16. data suggest that TSG-6 expression might be essential in endometrial matrix organization and feto-maternal communication during the implantation process. PMID: 24213015
17. the HA-binding site defined here may not play a role in TSG-6-mediated transfer of heavy chains from inter-alpha-inhibitor onto HA, a process known to be essential for ovulation. PMID: 24403066
18. TSG-6 suppresses CXCL8-mediated chemotaxis of neutrophils; this lower potency effect might be important at sites where there is high local expression of TSG-6. PMID: 24501198
19. This study provides insight into what we believe to be a previously undescribed multifaceted role of mesenchymal stem cell-released TSG-6 in wound healing. PMID: 23921952
20. Data indicate that TSG-6-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44-positive cells. PMID: 24005673
21. The protein product of tumor necrosis factor-alpha stimulated gene-6 strongly correlated with ossification markers and hyaluronidase in calcified human aortic valves. PMID: 23017666
22. This review discusses TSG-6 as a potential molecular marker of oocyte maturation. PMID: 22922154
23. TSG-6 increases the accumulation of HA in the cell-associated matrix, partially by preventing its dissolution from the cell-associated matrix into the conditioned medium, but primarily by inducing HA synthesis PMID: 23129777
24. analysis of irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6 PMID: 23166324
25. TSG-6 reverts the inhibitory effects exerted by PTX3 on FGF2-mediated angiogenesis through competition of FGF2/PTX3 interaction. PMID: 22267482
26. TSG-6 was central to EMT through effects on HA macromolecular structure and through CD44-dependent triggering of cell responses. PMID: 21864707
27. TSG-6 is a potent HA cross-linking agent PMID: 21596748
28. TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin. PMID: 21566135
29. negative correlation between TSG-6 expression levels and severity of capsular contracture (CC) suggests a possible protective role for TSG-6 in the context of CC formation, and this may have a clinically relevant role in prevention of breast CC PMID: 21239672
30. TSG-6/HC2 link heavy chains randomly on the chondroitin sulfate chain of bikunin, in contrast to the ordered attachment observed during the biosynthesis. PMID: 20463016
31. polymorphism in osteoarthritis; chromosome location given here (chromosome 2) PMID: 11854277
32. TSG-6 is a multifunctional protein associated with inflammation [review] PMID: 12692188
33. Tumor necrosis factor, alpha-induced protein 6 activates an anti-inflammatory agent- inter-alpha-inhibitor[review]. PMID: 14515153
34. The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link. PMID: 15653696
35. This TSG-6 model reveals the residues most likely to be involved in stabilizing the inter-Link module interface, which are highly conserved across the Link protein/ chondroitin sulfate proteoglycan subfamily. PMID: 15718240
36. TSG-6 treatment also resulted in a rapid increase in cyclooxygenase-2 (COX-2) mRNA levels, suggesting that TSG-6 up-regulates COX-2 gene expression PMID: 15809059
37. TSG-6 acts as cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes PMID: 15840581
38. heparin with the Link module significantly increases the anti-plasmin activity of the TSG-6.IalphaI complex; TSG-6 is likely to contribute to matrix remodeling, at least in part, through down-regulation of the protease network PMID: 15917224
39. The tumor necrosis factor alpha induced protein 6 is a potential marker that could be used for early diagnosis and prognosis of cancerous or precancerous lesions. PMID: 16467113
40. hyaluronan synthase 2 and TSG-6 have roles in hyaluronan distribution and function in proximal tubular epithelial cells PMID: 16687630
41. Evidence is cited in this review that TSG-6 can regulate the expression of various molecules that have important roles in the control of inflammation. PMID: 16709183
42. TSG-6 is down-regulated during osteoblastic differentiation, and suppressed osteoblastic differentiation induced by both BMP-2 and osteogenic differentiation medium. PMID: 16771708
43. TSG-6 may play an important protective role in bronchial epithelium by increasing the antiprotease screen on the airway lumen. PMID: 16873769
44. Crystallography data on the free protein, and (15)N NMR relaxation data for the uncomplexed and HA(8)-bound forms of Link_TSG6, is presented. PMID: 17585936
45. TSG-6 is a high affinity ligand that can mediate fibronectin interactions with other matrix components and modulate some interactions of fibronectin with cells PMID: 18042364
46. 3 genes were upregulated in patients with chronic EBV infection: guanylate binding protein 1, tumor necrosis factor-induced protein 6, and guanylate binding protein 5; they may be associated with the inflammatory reaction or with cell proliferation. PMID: 18260761
47. The transfer of heavy chains from bikunin proteins to hyaluronan requires both TSG-6 and HC2. PMID: 18448433
48. TSG-6 has dual roles in bone remodeling: it inhibits RANKL-induced bone erosion in inflammatory diseases, and its interactions with BMP-2 and RANKL help to balance mineralization by osteoblasts and bone resorption by osteoclasts PMID: 18586671
49. TSG-6 transfers proteins between glycosaminoglycans via a Ser28-mediated covalent catalytic mechanism PMID: 18820257
50. myelomonocytic cells and MoDC are a major source of TSG-6 and that PTX3 and TSG-6 are coregulated PMID: 19389798
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組織特異性：

Found in the synovial fluid of patients with rheumatoid arthritis.
數據庫鏈接：

HGNC: 11898

OMIM: 600410

KEGG: hsa:7130

STRING: 9606.ENSP00000243347

UniGene: Hs.437322

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