TMEM106B Antibody
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中文名稱：TMEM106B兔多克隆抗體
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貨號：CSB-PA023674GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：TMEM106B
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別名：2310036D22Rik antibody; 5830455K21Rik antibody; 6430519M21Rik antibody; AI428776 antibody; AI661344 antibody; FLJ11273 antibody; LRRGT00101 antibody; MGC33727 antibody; MGC94135 antibody; T106B_HUMAN antibody; Tmem106b antibody; Transmembrane protein 106B antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Human TMEM106B
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.
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基因功能參考文獻：
- TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. PMID: 30013069
- These findings illustrate the profound effect of TMEM106B haplotypes on brain health and highlight the importance to better understand TMEM106B's function and dysfunction in the context of neurodegenerative diseases. PMID: 29970152
- This study demonstrated that in Chinese patient minor alleles of rs1990622 and rs3173615 in TMEM106B may be associated with PD patients with initial symptom of rigidity/bradykinesia. PMID: 28477711
- Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD). PMID: 28888721
- A common causal variant underlying both association with disease and association with TMEM106B expression in lymphoblastoid cell lines. PMID: 29056226
- Study developed a TMEM106B transgenic mouse model that recapitulates the interaction between progranulin and TMEM106B in human patients and supports a regulation of TMEM106B by progranulin in the aged brain and a role of TMEM106B in frontotemporal lobar degeneration-progranulin disease progression. PMID: 28126008
- This review revealed TMEM106B variants as significant contributors to one's risk of developing various TDP-43 proteinopathies, both in patients harboring disease-causing mutations and in subjects with TDP-43 pathology of unknown cause. PMID: 27543298
- TMEM106B enhances the benefit of cognitive reserve on brain structure in fronto-temporal dementia. PMID: 28460069
- we expanded our understanding of the TMEM106B haplotype that is protective against TDP-43 proteinopathy. PMID: 28441426
- These findings suggest that the up-regulation of TMEM106B may increase the risk of frontotemporal lobar degeneration by directly causing neurotoxicity and a pathological phenotype linked to FTLD-TDP. PMID: 27563066
- Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. The roles of SNPs T185, S185, or S134N in endosomal sorting complexes required for transport were studied. T185 is a risk factor in neurodegeneration with endolysosomal defects. PMID: 26651479
- Study suggests that TMEM106B is associated with frontotemporal dementia, although the extent of this effect is difficult to be estimated by using clinical frontotemporal dementia series PMID: 25096617
- It is a risk factor for frontotemporal lobar degeneration. PMID: 25085782
- TMEM106b variability does not influence Alzheimer disease risk or plasma progranulin levels. PMID: 25114081
- Common variants in TMEM106B serve as a distinct risk factor for TDP-43 pathology in older persons without frontotemporal lobe dementia. PMID: 25653292
- The HpScl groups (Hippocampual Sclerosis and Hippocampual Sclerosis-AD) were more likely to exhibit genetic variants in TMEM106B that are associated with frontotemporal lobar degeneration. PMID: 24899141
- results show that, in nondemented persons, TMEM106B influences the volume of temporal brain regions that are important for language processing. PMID: 24731779
- Neuronal TMEM106B plays a central role in regulating lysosomal size, motility and responsiveness to stress, highlighting the possible role of lysosomal biology in FTLD-TDP. PMID: 25066864
- Data provide an initial neuropathological characterization of the newly discovered frontotemporal lobar degeneration-associated protein TMEM106B PMID: 24252750
- This study confirmed that specific TMEM106B single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease. PMID: 25470345
- Study identifies TMEM106B as the first genetic factor modifying disease presentation in C9ORF72 expansion carriers PMID: 24385136
- Study demonstrates that TMEM106B is the first reported genetic modifier in C9orf72 expansion-related frontotemporal lobar degeneration PMID: 24442578
- This study demonstrate that TMEM106B and APOE interact to increase late-onset Alzheimer's disease in Han Chinese. PMID: 24166182
- Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). PMID: 24872421
- These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport. PMID: 24357581
- TMEM106B polymorphism modulates brain connectivity in granulin mutation carriers. PMID: 24343233
- These findings suggest that low TMEM106B levels might protect against frontotemporal lobar degeneration TAR DNA binding protein 43 in these patients PMID: 23742080
- TMEM106B is localized in the late endosome/lysosome compartments and TMEM106B levels are regulated by lysosomal activities. PMID: 23136129
- This study demonistrated that aberrant overexpression of TMEM106B affects the distribution and intracellular levels of progranulin, suggesting that the two proteins may act in the same pathogenic pathway in FTLD-TDP. PMID: 22895706
- Our data implicate TMEM106B in the pathological presentation of Alzheimer Disease. PMID: 22855871
- Endogenous as well as overexpressed TMEM106B localizes to late endosomes and lysosomes. Interestingly, the inhibition of vacuolar H(+)-ATPases significantly increased the levels of TMEM106B. PMID: 22511793
- Our results suggest that genetic variation in TMEM106B (rs1990622) may influence risk for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) by modulating secreted levels of GRN. PMID: 21220649
- FTLD-TDP risk gene TMEM106B is involved in the development of cognitive impairment in amyotrophic lateral sclerosis. PMID: 21104415
- This study strongly supported TMEM106B as a risk gene for frontotemporal lobar degeneration. PMID: 21354975
- The genome-wide association study revealed a strong association between FTLD-TDP and several single nucleotide polymorphisms (SNPs) that mapped in the region of the TMEM106B gene PMID: 20383883
- Variants in TMEM106B are strong risk factors for frontotemporal lobar degeneration with TDP-43 inculsions. PMID: 20154673
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相關疾病：Ubiquitin-positive frontotemporal dementia (UP-FTD); Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (FTDALS1)
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亞細胞定位：Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein. Membrane; Lipid-anchor.
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蛋白家族：TMEM106 family
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組織特異性：Expressed in frontal cortex.
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數據庫鏈接：
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