TLR3 Antibody

說明書

中文名稱：

TLR3兔多克隆抗體
貨號：

CSB-PA218546
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA218546(TLR3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA218546(TLR3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, Raji cells, K562 cells, Primary antibody: CSB-PA218546(TLR3 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O15455
基因名：

TLR3
別名：

CD283 antibody; CD283 antigen antibody; IIAE2 antibody; TLR 3 antibody; Tlr3 antibody; TLR3_HUMAN antibody; Toll Like Receptor 3 antibody; Toll-like receptor 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human TLR3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
基因功能參考文獻：
1. study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway. PMID: 29273868
2. We report a significant association between TLR3 L412F and persistent clinical disease in two cohorts of Irish and American Caucasians with pulmonary sarcoidosis. This study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and reveals TLR3 L412F as a candidate biomarker. PMID: 29237089
3. Data indicate that trigeminal ganglion (TG) neurons are vulnerable to HSV-1 because they require preemptive stimulation of the Toll-like receptor 3 (TLR3) to induce antiviral immunity. PMID: 30154162
4. These variations in the TLR3mediated signaling pathway molecules suggested that oxidative stress may be a key regulator for TLR3 activation during RSV infection PMID: 29845280
5. In conclusion, we demonstrated that EV71 infection induced elevated expressions of TLR3/4 and Notch1/2 in CD14+ monocytes. PMID: 29702280
6. Increased TLR3 expression in acute exacerbations of chronic obstructive pulmonary disease patients is associated with declining lung function PMID: 29264743
7. Data show that regenerating family member 3 alpha protein (REG3A) can modulate specific cutaneous inflammatory responses and that the decrease in cutaneous REG3A exacerbates toll-like receptor 3 (TLR3)-mediated inflammation in diabetic skin wounds. PMID: 27830702
8. These data indicate a novel role of the TLR3-TICAM-1 pathway in controlling miR-21 levels in extracellular vesicles. PMID: 29679565
9. The TLR3.rs3775290 "CC" genotype was associated with hepatitis C virus chronicity, while the TLR9 gene may not play a major role in hepatitis C virus infection. PMID: 29860675
10. CYLD inhibits post-transcriptional regulation of RIG-I and MDA5 expression following TLR3 activation in MCs. CYLD may be involved in the pathogenesis of CKD PMID: 29166644
11. These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response. PMID: 29742501
12. Reduced response of NK cells to TLR3 stimulation in children with recurrent infections has been observed. PMID: 29975469
13. Using hepatocyte-based culture models for Hepatitis C virus (HCV) infection, we found a portion of HCV dsRNA intermediates to be released from infected cells in extracellular vesicles, which reduces activation of toll-like receptor 3. PMID: 29535029
14. the association between TLR3, TLR4 variants and nine IL-6 polymorphisms, and response to anti-viral treatment during hepatitis C infection. PMID: 28823914
15. results suggest that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis. PMID: 27031066
16. The current study suggests that TLR3 signaling induces CCL5 expression via NF-kappaB and IRF3 in bile duct cells, and this pathway may be involved in the pathogenesis of BA. PMID: 29070776
17. The down regulation of TRIF, TLR3, and mitochondrial antiviral signaling protein (MAVS) expressions in chronic hepatitis C correlates with the disease severity and the outcome of hepatitis C virus infection PMID: 28480979
18. this study signifies that TLR3 adaptor molecules are necessary for the proper production of cytokines, chemokines and pro-labour mediators after TLR ligation PMID: 28844021
19. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity. PMID: 27270888
20. Increased expressions of TLR-3, TLR-4 and CD80 mRNA and the level of urinary CD80/creatinine could be useful markers to differentiate patients of steroid-sensitive nephrotic syndrome in relapse from those with steroid-resistant nephrotic syndrome. PMID: 28210837
21. TRIM56 may act as a tumor suppressor in multiple myeloma through activation of TLR3/TRIF signaling pathway. PMID: 29214775
22. p53 mutants that retain the ability to transactivate TLR3, can be used together with the TLR3 agonist polyinosinic-polycytidylic acid (poly(I:C) to alter immune responses mediated by this receptor, and subsequently increase TLR3-mediated apoptosis PMID: 27533082
23. Positive rates of iNOS in cervical tissues were 72.1%, 28.2%, and 3.1% in the -HPV-positive patients with cervical cancer (CC group), HR-HPV group, and controls, respectively (P < 0.05). Levels of TLR3, TLR4, TLR7, TLR8, NF-kappaB p65, and iNOS in cervical epithelial cells were higher in CC group than in other groups. PMID: 28626766
24. TLR signaling, in particular TLR3 activation, can efficiently reactivate HIV transcription in infected microglia, but not in monocytes or T cells PMID: 28166799
25. TLR3 stimulation induces the Warburg effect in head and neck squamous carcinoma cells in vitro, and suggest that TLR3 may play a role in tumor adaptation to hypoxia. PMID: 27791989
26. we report that autophagy is associated with apoptosis processes, involving LC3 and TRIF-colocation in human HCC cells. Regulation of autophagy and the TLR3-TRIF pathway may be effective in the treatment of liver cancer. PMID: 27338037
27. Polymorphism of CD209 and TLR3 genes in populations of North Eurasia PMID: 29368829
28. TLR3-activated signaling enhanced the therapeutic effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of colitis PMID: 27649928
29. the TLR3 Leu412Phe CC genotype is independently associated with severity of hepatitis C recurrence after LT. PMID: 27101936
30. These data demonstrate that in the absence of HBsAg, hepatic hepatitis B virus replication leads to Tlr3-dependent interferon responses in non-parenchymal liver cells. PMID: 27121087
31. Study found that the astrocytic TLR3-mediated cytokine expression profile is modulated by prostaglandin, and NF-kappaB, ERK1/2 and GSK-3beta are involved in the modulatory mechanism. These results suggest that pathological conditions with increased COX activity can neuroimmunologically alter neuron-glia interaction. PMID: 25014275
32. Activation of TLR3 and TLR4 stimulated the expression of HIF-1 through NF-kappaB in oral squamous cell carcinoma PMID: 27191981
33. The present study investigated the effects of vitamin D3 on the expression of TLR3, TLR7, and TLR9 in Systemic lupus erythematosus patients. PMID: 28544067
34. TLR3 or TLR4 activation of mesenchymal stem cells increases Treg cell induction via the Notch pathway PMID: 27571579
35. Data suggest that, unlike non-metastatic intestinal epithelial cells (IECs), metastatic IECs express TLR3 and that TLR3 agonists induce inflammatory cytokine (CXCL10) production and promote invasiveness of IECs. (TLR3 = toll-like receptor 3; CXCL10 = chemokine [C-X-C motif] ligand 10 protein) PMID: 28717003
36. TLR3-activated macrophages release exosomes that contain anti-HCV microRNA (miRNA)-29 family member PMID: 27605546
37. homozygous IFITM3 CC and TLR3 CC genotypes showed significant independent associations with higher death risks in H7N9/H1N1pdm09 influenza in a large Chinese cohort PMID: 28510725
38. TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti-oxidative response. PMID: 27805282
39. Ligand-driven triggering of TLR-3, -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells. PMID: 28266028
40. Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1), RIP1, and IRAK1, we hypothesize that SH exerts its NF-kappaB activation inhibitory function by interacting with TNFR1, interleukin-1 receptor type 1 (IL-1R1), and TLR3 complexes in the plasma membrane of infected cells. PMID: 28659487
41. Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine secretion in the lung and promoting neutrophil recruitment. PMID: 27505671
42. the L412F polymorphism in the TLR3 gene could be a genetic risk factor for the development of human cytomegalovirus disease PMID: 28046022
43. Studied Toll-like receptor 3 (TLR3) mutations in a cohort of 11 adult Italian viral encephalitis patients. PMID: 28368532
44. This study concluded that M. catarrhalis reduces antiviral defense functions of bronchial epithelial cells, which may increase susceptibility to viral infections. PMID: 26979086
45. Report PD-1/PD-L1 and TLR3 expression in malignant pleural mesotheliomas as possible tests for selection patients who could benefit from immunotherapy. PMID: 26980049
46. LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immunodeficiency and autoinflammation. PMID: 27810922
47. found that TLR3 signaling induces the expression of IFI35, and IFI35 negatively regulates IFN-beta-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells. This suggests that IFI35 expressed in astrocytes may play an important role in regulating the innate immune system in astrocytoma cells. PMID: 28109979
48. COPD lung tissue explants showed a greater pro-inflammatory response to TLR3 or TLR7/8 activation than control smokers. PMID: 27729782
49. frequency of TLR3 c.1377 TT homozygous mutant genotype in the Crimean-Congo hemorrhagic fever (CCHF) patients was higher than that of the healthy controls in the clinical settings; in conclusion, presence of TLR3 c.1377 TT genotype may have a role in the susceptibility to CCHF PMID: 26959380
50. TLR-3 c.1377 T-allele was associated with advanced stage of hepatic fibrosis in Egyptian patients. Frequency of polymorphic genotypes in TLR-3 (_7 C/A), TLR-3 (c.1377C/T) and TLR-9 (1237T/C) were not significantly different between studied HCV-positive patients and controls. PMID: 28093541
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相關疾病：

Herpes simplex encephalitis 2 (HSE2)
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
蛋白家族：

Toll-like receptor family
組織特異性：

Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain,
數據庫鏈接：

HGNC: 11849

OMIM: 603029

KEGG: hsa:7098

STRING: 9606.ENSP00000296795

UniGene: Hs.657724

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