TLE1 Antibody
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中文名稱：TLE1兔多克隆抗體
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貨號：CSB-PA023585GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：E(Sp1) homolog antibody; Enhancer of split groucho 1 antibody; Enhancer of split groucho like protein 1 antibody; Enhancer of split groucho-like protein 1 antibody; ESG antibody; ESG1 antibody; GRG1 antibody; TLE1 antibody; TLE1_HUMAN antibody; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila) antibody; Transducin like enhancer of split 1 antibody; Transducin like enhancer of split 1 homolog of Drosophila E(sp1) antibody; Transducin like enhancer protein 1 antibody; Transducin-like enhancer protein 1 antibody
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反應種屬：Human,Mouse,Rat
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免疫原：Human TLE1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
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基因功能參考文獻：
- The majority of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumor cases showed some TLE1 immunoreactivity (n = 16; 89% for >/=1 + staining); 14 (78%) of total cases showed >/=2 + positivity using any of the 3 scoring systems. Over half (n = 10; 56%) of cases showed >/=2 + staining; 4 (22%) cases showed 3 + strong and diffuse TLE1 staining measured by all scoring systems in agreement. PMID: 29490565
- Immunohistochemical analysis for TLE1 can identify basal cell adenomas and basal cell adenocarcinomas by luminal cell staining difference, especially indistinct luminal cell expression for TLE1 in invasive areas of BCAC. PMID: 30053869
- TLE1 is a potential immunohistochemical marker for glomus tumors PMID: 28632567
- studies indicate Bit1 is an inhibitor of EMT and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness PMID: 27655370
- Authors present data indicating that TLE1 is rapidly excluded from the nucleus following epidermal growth factor receptor pathway activation, an effect that likely accounts for its inability to mediate effective repression under such conditions. PMID: 28192406
- TLE1 is not a stand-alone diagnostic immunohistochemical marker for synovial sarcoma PMID: 27568668
- Data suggest TLE1 is highly expressed in macrophages cultured in vitro, in macrophages of atherosclerotic plaques, and in macrophages of visceral adipose tissue from obese women; expression of TLE1 is up-regulated upon macrophage activation. PMID: 26763127
- TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin PMID: 25446087
- There was no difference in TLE-1 staining between different subtypes of synovial sarcoma PMID: 24422953
- GrG1 is involved in pancreatic cell differentiation, establishing a monohormonal beta cell identity. Grg1 is the predominant Groucho expressed in human beta-cells but acts functionally similarly to Grg3. PMID: 24487024
- TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
- highly specific biomarker for synovial sarcoma PMID: 23197007
- signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (TLE). PMID: 23775085
- Although molecular confirmation is the diagnostic gold standard for synovial sarcoma, TLE1, in view of its high sensitivity may be a useful marker within the optimal IHC panel comprising EMA, BCL2, MIC2, CD34 and CK7 PMID: 23287123
- TLE1 is selectively upregulated in invasive breast tumors relative to noninvasive ductal carcinoma in situ and normal mammary epithelial tissues. PMID: 22952044
- TLE1, is a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions. PMID: 21536917
- Epistatic and biological interactions between TLE1 and NOD2 are involved in inflammatory bowel disease pathogenesis. PMID: 21699783
- TLE1 is a critical factor for the survival of synovial sarcomas PMID: 21319215
- Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1. PMID: 20181723
- Biologically, loss of TLE-dependent rRNA gene repression coincides with increased global protein synthesis and enhanced cell proliferation PMID: 20160071
- Hyperphosphorylation induced by cofactor binding plays a positive role in the regulation of Gro/TLE1 anti-neurogenic activity. PMID: 19956621
- The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain PMID: 12030375
- 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions PMID: 12057191
- Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
- beta-catenin displaces Groucho/TLE from Tcf/Lef by binding to a previously unidentified second, low-affinity binding site on lymphoid enhancer factor 1 PMID: 15768032
- ESG1 expression in human cells is studied. PMID: 16166252
- TLE is a robust immunohistochemical marker for synovial sarcoma in humans. PMID: 17255769
- interaction between Sirt1 and TLE1 is important for mediating repression of NF-kappaB activity PMID: 17680780
- Knockdown of TLE1 or TLE4 levels increased the rate of cell division of the AML1-ETO-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 or TLE4 caused apoptosis and cell death. PMID: 18258796
- data suggest that TLE1 epigenetic inactivation contributes to the development of hematologic malignancies by disrupting critical differentiation and growth-suppressing pathways PMID: 18519670
- Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides PMID: 18611861
- Results demonstrate that transcriptional repression by PRH is dependent on TLE availability and suggest that subnuclear localization of TLE plays an important role in transcriptional repression by PRH. PMID: 18713067
- TLX1 interacts with TLE1 via an Eh1-like motif. PMID: 19250647
- TLE1 expression is by no means specific for synovial sarcoma, being present in a number of tumors, which enter its differential diagnosis. PMID: 19363472
- Findings confirm, in a prospective diagnostic context, that TLE1 is more sensitive and specific for synovial sarcoma than any other currently available immunohistochemical stains. PMID: 19809272
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亞細胞定位：Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
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蛋白家族：WD repeat Groucho/TLE family
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組織特異性：In all tissues examined, mostly in brain, liver and muscle.
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數據庫鏈接：
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