THNSL2 Antibody
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中文名稱：THNSL2兔多克隆抗體
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貨號(hào)：CSB-PA023500GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：THNSL2
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別名：THNSL2 antibody; Threonine synthase-like 2 antibody; TSH2 antibody; EC 4.2.3.- antibody; Secreted osteoclastogenic factor of activated T-cells antibody; SOFAT antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human THNSL2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.; Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
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基因功能參考文獻(xiàn)：
- Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women. PMID: 26480920
- These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. PMID: 27035849
- may exacerbate inflammation and support osteoclast formation and bone destruction PMID: 25916677
- The present study demonstrated that SOFAT may play an important role in periodontitis. PMID: 23619471
- THNSL2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
- A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 production and osteoclast formation in the absence of osteoblasts or RANKL. It is insensitive to RANKL inhibitor osteoprotegerin. PMID: 19877052
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亞細(xì)胞定位：[Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
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蛋白家族：Threonine synthase family
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數(shù)據(jù)庫鏈接：
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