TFDP1 Antibody

說明書

中文名稱：

TFDP1兔多克隆抗體
貨號：

CSB-PA203580
規格：

￥2024
圖片：
Western blot analysis of extracts from Hela, HUVEC and HepG2 cells using DP-1 Antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TFDP1 Polyclonal antibody
Uniprot No.：

Q14186
基因名：

TFDP1
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Peptide sequence around aa.13~17(E-L-K-V-F) derived from Human DP-1
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
基因功能參考文獻：
1. COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer. PMID: 27871936
2. Here, the authors show that an acidic region of DP1, whose function has remained elusive, binds to the plekstrin homology (PH) domain of the p62 subunit of TFIIH that contributes to transcriptional activation. PMID: 27825926
3. role for E2F1 and TFDP1 in the transcriptional regulation of PITX1 in articular chondrocytes PMID: 27802335
4. According to our study results, the gene TFDP1 and the cell cycle pathway are strongly associated with high-grade glioblastoma multiforme (GBM); this result may provide new insights into the pathogenesis of GBM. PMID: 27323154
5. Amplification of CUL4A, IRS2, and TFDP1 genes showed a significant difference in disease-free survival by both univariate and multivariate survival analyses in intrahepatic cholangiocarcinoma. PMID: 26684807
6. The TFDP1 indel84 mutation generates a gain-of-function phenotype by increasing cell proliferation, migration, and invasion of colorectal cancer cells. PMID: 25133581
7. somatic mutations in DP-1 uncouple normal control of the E2F pathway, and thus define a new mechanism that could contribute to aberrant proliferation in tumor cells PMID: 23934193
8. The authors demonstrate that adenovirus E1A binds to E2F/DP-1 complexes through a direct interaction with DP-1 and may selectively activate a subset of E2F-regulated cellular genes during infection. PMID: 21715488
9. the DP-1 "Stabilon" domain was a C-terminal acidic motif and was quite important for DP-1 stability. PMID: 20513349
10. 13q34 amplification may be of relevance in tumor progression of breast cancers by inducing overexpression of CUL4A and TFDP1, important in cell cycle regulation. These genes were also overexpressed in non-basal-like tumor samples. PMID: 19995430
11. TFDP1, CUL4A, and CDC16 are probable targets of an amplification mechanism and therefore may be involved, together or separately, in development and/or progression of some hepatocellular carcinomas PMID: 12029633
12. expression of the transcription factor DP-1 and its heterodimeric partner E2F-1 in non-Hodgkin lymphoma PMID: 12607600
13. TFDP1 may have a role in progression of some hepatocellular carcinomas by promoting growth of the tumor cells PMID: 14618416
14. DP-1alpha is a novel isoform of DP-1 that acts as a dominant-negative regulator of cell cycle progression PMID: 15863509
15. DP1 is a critical direct target of ARF. PMID: 16135794
16. SOCS-3 acts as a negative regulator of the cell cycle progression under E2F/DP-1 control by interfering with heterodimer formation between DP-1 and E2F PMID: 18687693
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

E2F/DP family
組織特異性：

Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
數據庫鏈接：

HGNC: 11749

OMIM: 189902

KEGG: hsa:7027

STRING: 9606.ENSP00000364519

UniGene: Hs.79353

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