TFC3 Antibody

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文獻引用 (1) 說明書

產品詳情

Uniprot No.：

P34111
基因名：

TFC3
別名：

Transcription factor tau 138 kDa subunit (TFIIIC 138 kDa subunit) (Transcription factor C subunit 3) TFC3 TSV115 YAL001C FUN24
反應種屬：

Escherichia coli(strain K12)
免疫原：

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TFC3 protein
免疫原種屬：

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Protein G
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

RNA polymerase III transcription machinery and tRNA processing are regulated by the ubiquitin ligase Rsp5 A ?opusińska, M Tys, M Boguta, M Cie?la,Biochimica et Biophysica Acta (BBA) - Molecular Cell Research,2025

功能：

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.
基因功能參考文獻：
1. tau55-HPD and Huf as bona fide protein phosphatases, characterize their substrate specificities, and provide a small set of regulated phosphosite targets in vivo. PMID: 23569204
2. the TFC6 promoter is directly regulated by the TF(III)C complex, a demonstration of an RNA polymerase II promoter being directly responsive to a core Pol III transcription factor complex. PMID: 21536876
3. Partially assembled Pol III complexes containing only the TFIIIC exhibit chromatin boundary functions both as heterochromatin barriers and as insulators to gene activation. PMID: 18849469
亞細胞定位：

Nucleus. Mitochondrion.
數據庫鏈接：

KEGG: sce:YAL001C

STRING: 4932.YAL001C

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