TFAP4 Antibody
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中文名稱：TFAP4兔多克隆抗體
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貨號：CSB-PA023419GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：TFAP4
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別名：Activating enhancer binding protein 4 antibody; Activating enhancer-binding protein 4 antibody; AP 4 antibody; AP4 antibody; bHLHc41 antibody; Class C basic helix-loop-helix protein 41 antibody; TFAP 4 antibody; TFAP4 antibody; TFAP4 protein antibody; TFAP4_HUMAN antibody; Transcription factor AP 4 antibody; Transcription factor AP-4 antibody; Transcription factor AP4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TFAP4
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
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基因功能參考文獻：
- these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment. PMID: 28981098
- Results show that AP4 is overexpressed in primary carcinoma compared with the non-cancerous mucosa and is up-regulated in EMT in colorectal cancer (CRC) cells. Its overexpression is correlated with liver metastasis in CRC and poor outcome. Also, The study show that USP22 binds to the promoter region of AP4 to activate its transcription. PMID: 28427243
- Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma and that high levels of this transcription factor are associated with poor clinical outcome in this disease. PMID: 27448979
- Depletion of either Arl5b or AP4 results in the accumulation of APP. PMID: 28000370
- results indicate that AP4 is a central mediator and coordinator of cell cycle progression PMID: 25261373
- the 16 SNP variants studied in the genes encoding the four units of AP-4 do not have a major role in overall CP, but SNP rs1217401 of AP4B1 is significantly associated with the risk of CP as a sequela of neonatal HIE in the Chinese population. PMID: 24065543
- betaTrCP-dependent degradation of TFAP4 is required for the fidelity of mitotic division PMID: 24500709
- Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss. PMID: 23949224
- Elevated AP4 expression in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival. Findings imply AP4 as a new regulator of epithelial-mesenchymal transition that contributes to metastatic processes in CRC PMID: 23752226
- findings provide evidence that a high expression level of AP-4 serves as a biomarker for poor prognosis for hepatocellular carcinoma PMID: 23055200
- The expression of AP-4 was silenced by the siRNAs transfection. PMID: 22615908
- Overexpression of AP-4 is associated with gastric carcinoma. PMID: 21336989
- in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter. PMID: 21719561
- Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer. PMID: 18480385
- Docking studies showed that the ATF4 DpSGIXXpSXE motif fits the binding pocket of beta-TrCP through an S-turning conformation. PMID: 18052253
- c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. PMID: 18818310
- AP-4 participates in a transcriptional-regulating complex at the HDM2-P2 promoter in response to DNA damage. PMID: 19505873
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亞細胞定位：Nucleus.
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數據庫鏈接：
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