TFAP2A Antibody
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中文名稱：TFAP2A兔多克隆抗體
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貨號(hào)：CSB-PA178989
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from COLO205 cells, using AP-2 antibody. -
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using AP-2 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TFAP2A Polyclonal antibody
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Uniprot No.：
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基因名：TFAP2A
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from Human AP-2.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
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基因功能參考文獻(xiàn)：
- The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development. PMID: 27933721
- Results show that gout-associated increased NRBP1 expression is regulated through methylation-dependent TFAP2A binding to the B1 region, which might be involved in the pathogenesis of gout. PMID: 28932319
- our results indicate that AP-2alpha can reverse the Multidrug resistance (MDR) of gastric cancer cells, which may be realized by inhibiting the Notch signaling pathway. PMID: 28439677
- High-confidence AP2alpha-binding peaks were detected in the regulatory regions of many target genes involved in the development of facial tissues including MSX1, IRF6, TBX22, and MAFB. In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2alpha consensus sequence. PMID: 24641171
- We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients PMID: 27663566
- We identified miR-1254 as a negative regulator inhibiting HO-1 translation by directly targeting HO-1 3'UTR via its seed region, and suppressing HO-1 transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1. PMID: 28749936
- dimerization-defective mutant of Nef failed to interact with either CD4 or AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recruitment as well as CD4 down-regulation PMID: 28031466
- Data show that TFAP2A binds many of the same regulatory elements as MITF in melanocytes. PMID: 28249010
- the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF PMID: 27866707
- AP-2a is an important transcription factor of DEK expression, which is correlated with the methylation level of the DEK core promoter in hepatocellular carcinoma . PMID: 27499261
- AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration PMID: 26780928
- role in the expression of Latent membrane protein 1 PMID: 26819314
- Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha. PMID: 26073327
- Results indicate that AP-2alpha activates COX-2 expression to promote NPC growth. PMID: 25669978
- The AP-2alpha transcription factor may play an important role in suppressing glioma progression. PMID: 25674231
- TFAP2A might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID: 25953442
- INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. PMID: 25358080
- Human melanomas display higher than normal CpG DNA methylation at the TFAP2A promoter.Aberrant CpG DNA methylation as an epigenetic mark associated with TFAP2A silencing in human melanoma. PMID: 25625848
- ETS1 induction of syncytiotrophoblast marker genes likely results in part from transactivation by activator protein-2alpha. PMID: 25651508
- Direct sequencing of the coding region of the TFAP2A gene revealed missense mutations in four branchio-oculo-facial syndrome patients; one patient was observed to have a previously described mutation (p.Arg251Gly), while three patients from two families were found to have novel mutations: p.Arg213Ser and p.Val210Asp. PMID: 25590586
- AP-2alpha continues to be required after lens vesicle separation to maintain a normal lens epithelial cell phenotype and overall lens integrity and to ensure correct fiber cell differentiation. PMID: 24753151
- Cigarette smoke condensate decreased AP-2alpha expression by suppressing its transcription in human lung cancer cell lines, particularly in p53-deficient NCI-H1299 cells. PMID: 25050743
- AP2-mediated receptor internalization can be dissociated from AP2-mediated chemotaxis PMID: 24450359
- During pregnancy, regulation of hCG beta subunit genes expression correlates with both methylation of their promoters and TFAP2A expression level. PMID: 25063728
- TFAP2A regulates nasopharyngeal carcinoma growth and survival through the modulation of the HIF-1alpha-mediated VEGF/PEDF signaling pathway. PMID: 24335623
- These data define a mechanism through which AP-2alpha acetylation and increased promoter access induce the expression of the TLR2 gene. PMID: 23680675
- Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
- The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas. PMID: 23660954
- Result suggests that the individual TFAP2A Branchio-Oculo-Facial Syndrome mutations can generate null alleles. These mutations combined with a role for AP-2alpha in epigenetic events, may influence the resultant pathology and the phenotypic variability. PMID: 23578821
- TFAP2C repressed CD44 expression in basal-derived breast cancer. PMID: 23764310
- Molecular modeling of the HIV-1 Nef C-terminal flexible loop in complex with AP2 suggests that M168L170 occupies a pocket in the AP2 sigma2 subunit. PMID: 23151229
- ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
- results indicate that Kctd15 acts in the embryo at least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the function of this critical factor in the neural crest induction hierarchy. PMID: 23382213
- Evidence of association was obtained with both single marker and haplotype analyses, thus providing a support for TFAP2A in non-syndromic cleft lip with or without cleft palate aetiology PMID: 21781438
- The different pattern of activator protein-2alpha expression in mild and severe preeclampsia clearly suggests that these conditions may have 2 independent pathogenic mechanisms. PMID: 22575257
- A mutation in the TFAP2A gene associated with Branchio-Oculo-Facial syndrome (heterozygous H384Y in exon 7) was found in both the proband and her mother. PMID: 22191992
- a robust transcriptional CTNNAL1 up-regulation occurs during acute ozone-induced stress and is mediated at least in part by ozone-induced recruitments of LEF-1 and AP-2alpha to the human CTNNAL1 promoter. PMID: 22359570
- fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted PMID: 22484487
- findings suggest that TFAP2A isoforms may be differentially regulated during breast tumourigenesis and this, coupled with differences in their transcriptional activity, may impact on tumour responses to tamoxifen therapy PMID: 21375726
- AP2 regulates the inhibin alpha subunit gene expression during trophoblast differentiation and may be a key regulator of syncytialization PMID: 21659426
- Data suggest that AP-2alpha plays an important role in tumor progression and that reduced AP-2alpha expression independently predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 21966377
- AP-2alpha regulation of CHRNA7 mRNA expression in multiple tissues during development PMID: 21979958
- Bcl-2 gene transcription is regulated by Ap2alpha-Rb complex binding to the Bcl-2 promoter. PMID: 21850486
- findings provide a better understanding of the epigenetic mechanisms that are involved in the loss of AP-2alpha protein in prostate cancer cells which lead to decreased cellular zinc uptake-a sine qua non of prostate cancer development PMID: 21940908
- Patients with Branchio-Oculo-Facial Syndrome (BOFS) and predominant ocular phenotypes can be diagnosed by upper lip examination. TFAP2A analysis provides diagnostic confirmation and improves genetic counselling. PMID: 21728810
- Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor. PMID: 20731749
- A protein-binding microarrays-based study of human healthy and breast tumor tissue extracts allowed the identification of previously unknown AP2alpha target genes. PMID: 21876733
- These data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2alpha. PMID: 21777522
- Multiple isoforms of AP-2alpha are highly expressed in pancreatic cancer cell lines including a new isoform, AP-2alpha variant 6, which seems to be pancreatic cancer specific and is deprived of transcriptional activity. PMID: 21654541
- this study provides further evidence regarding the role of IRF6 variations in non-syndromic cleft lip with or without cleft palate (NSCLP) development and finds no significant association between TFAP2A and NSCLP in this northern Chinese population. PMID: 21683068
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相關(guān)疾病：Branchiooculofacial syndrome (BOFS)
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亞細(xì)胞定位：Nucleus.
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蛋白家族：AP-2 family
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