TES Antibody

文獻引用 (1) 說明書

中文名稱：

TES兔多克隆抗體
貨號：

CSB-PA890679LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate
All lanes: TES antibody at 2.92µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 48, 47 kDa
Observed band size: 48 kDa

IHC image of CSB-PA890679LA01HU diluted at 1:800 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA890679LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
引用文獻
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TES Polyclonal antibody
Uniprot No.：

Q9UGI8
基因名：

TES
別名：

DKFZP586B2022 antibody; MGC1146 antibody; TES antibody; TES_HUMAN antibody; TESS 2 antibody; TESS antibody; TESS2 antibody; Testin antibody; Testis derived transcript (3 LIM domains) antibody; Testis derived transcript antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Testin protein (130-260AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，TES Antibody (CSB-PA890679LA01HU)，的標記方式是Non-conjugated。對于TES Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA890679LB01HU	TES Antibody, HRP conjugated	ELISA
FITC	CSB-PA890679LC01HU	TES Antibody, FITC conjugated
Biotin	CSB-PA890679LD01HU	TES Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway DH Lee,International journal of molecular sciences,2023

產(chǎn)品評價

靶點詳情

功能：

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.
基因功能參考文獻：
1. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes PMID: 28378594
2. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways. PMID: 27323777
3. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains PMID: 28542564
4. Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor. PMID: 28000866
5. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module. PMID: 26611125
6. we confirm that the TES promoter is unmethylated in normal adult and fetal tissues. Re-expression of TESTIN protein in acute lymphoblastic leukemia cells using expression plasmid transfection results in rapid cell death or cell cycle arrest. PMID: 26985820
7. Loss of TES gene expression is associated with nasopharyngeal carcinoma. PMID: 25824796
8. findings suggest that the TES gene is a novel tumor suppressor gene PMID: 25498217
9. TESTIN was hypermethylated in 43.7% endometrial cancer tissues (p < 0.001). Moreover, TESTIN hypermethylation was significantly correlated with advanced tumor stage, deep myometrial invasion and lymphatic node metastasis. PMID: 25720371
10. Downregulation of TES was associated with breast cancer. PMID: 25119600
11. TESTIN was commonly downregulated in human endometrial carcinoma and was associated with poor prognostic markers. PMID: 24929083
12. A further significant correlation was observed between TES downregulation and the luminal B subtype independent of survivin expression. PMID: 23715752
13. TES, as a valuable marker of breast cancer prognosis, plays an important role in the development and progression of breast cancer. TES may be an effective novel target in breast cancer prevention and treatment. PMID: 22957844
14. Low TES gene expression is associated with coronary artery disease. PMID: 22156939
15. Alterations of TES mRNA level may predict the location of metastasis. CAV1 possibly affect the cancer cell invasion PMID: 22201996
16. These results suggest an interplay between the CaR and testin in the regulation of CaR-mediated Rho signalling with possible effects on the cytoskeleton. PMID: 21843504
17. data implicate TES methylation in ALL and provide additional evidence for the involvement of LIM domain proteins in leukaemogenesis PMID: 20573277
18. results support the role of TES as a TSG in gastric carcinogenesis and that TES is inactivated primarily by LOH and CpG island methylation PMID: 20626849
19. The expression level of TES is significantly down-regulated in primary gastric cancer. PMID: 18799041
20. TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers. PMID: 20180808
21. TES is best candidate tumor suppressor gene at 7q31 in prostate tumors PMID: 15252854
22. Loss of TES from focal adhesions results in loss of actin stress fibres. PMID: 15662727
23. Oservations identify Tes as an atypical binding partner of EVH1 domain of Mena and a regulator specific to a single Ena/VASP family member. PMID: 18158903
24. Results suggest that testin has different conformational states in different cellular compartments, and a "closed" conformational state of TES may be involved in nucleolar localization. PMID: 18696217
25. Inactivation of TESTIN is involved in head and neck carcinogenesis through its downregulation. PMID: 19289703
顯示更多

收起更多
亞細胞定位：

Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers.
蛋白家族：

Prickle / espinas / testin family
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 14620

OMIM: 606085

KEGG: hsa:26136

STRING: 9606.ENSP00000350937

UniGene: Hs.592286

Most popular with customers

YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VIM Recombinant Monoclonal Antibody

Applications: ELISA, IHC, IF

Species Reactivity: Human