TCF7L2 Antibody
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中文名稱：TCF7L2兔多克隆抗體
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貨號：CSB-PA023307GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：HMG box transcription factor 4 antibody; hTCF 4 antibody; hTCF-4 antibody; T cell factor 4 antibody; T cell specific HMG box antibody; T cell specific transcription factor 4 antibody; T-cell factor 4 antibody; T-cell-specific transcription factor 4 antibody; TCF 4 antibody; TCF-4 antibody; TCF4 antibody; TCF7L2 antibody; TCF7L2 protein antibody; TF7L2_HUMAN antibody; Transcription factor 7 like 2 antibody; Transcription factor 7 like 2 T cell specific HMG box antibody; Transcription factor 7-like 2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human TCF7L2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
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基因功能參考文獻：
- Studied association of single nucleotide polymorphisms in Transcription factor 7-like 2 (TCF7L2) gene and genetic predisposition to type 2 diabetes in nonobese patients. PMID: 28263491
- The meta-analysis suggested that TCF7L2 polymorphism rs7903146 was significantly associated with type 2 diabetes mellitus in Caucasian, East Asian, South Asian and other ethnicities. [Meta-analysis] PMID: 29514658
- The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2. PMID: 30177026
- The two varients of the gene TCF7L2 are important genetic risk factors for the T2D development in the Han ethnic group in China. PMID: 30266127
- In conclusion, homozygous TT allele carriers show altered postprandial triglyceride response, mainly influencing very low density lipoproteins and high density lipoproteins subclasses suggesting a genotype-mediated effect on hepatic lipid regulation. PMID: 28220878
- a considerable connection of DEFB1 and TCF7L2 gene polymorphisms with nephrolithiasis PMID: 29959006
- stable knockdown of FOXO3, NCOA3, and TCF7L2 restored growth in low glucose but reduced MEK/MAPK phosphorylation, reduced anchorage-independent growth, and modulated expressions of GLUT1 and Ras pathway related proteins. PMID: 29301589
- Study showed the association of TCF7L2 SNPs (rs7903146, rs12255372, and rs10885406) with high total cholesterol/high-density lipoproteins ratio. Findings highlight the influence of TCF7L2 SNPs on altered lipid profile in the Balinese, which may further link to the risk of cardiovascular diseases. PMID: 30027476
- TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to diabetic nephropathy in Chinese Han population, but rs290487 is not. The strong linkage disequilibrium existed between the 2 single nucleotide polymorphisms and haplotype T-T (rs7903146-rs290487) increased the susceptibility to diabetic nephropathy. PMID: 30290587
- the T risk allele of the rs7903146 in the TCF7L2 gene increases the risk of type 2 diabetes, was determined. PMID: 29631902
- Common variation at TCF7L2 influences acute responses to both glipizide and metformin in people without diabetes and highlight altered incretin signaling as a potential mechanism by which TCF7L2 variation increases T2D risk. PMID: 29326107
- No correlation between the studied polymorphisms of the TCF7L2 gene and GDM was observed. PMID: 27958632
- Type 1 diabetes mellitus patients carriers of the TCF7L2 variant had a milder immunologic and metabolic phenotype at type 1 diabetes diagnosis, which could be partly driven by type 2 diabetes-like pathogenic mechanisms. PMID: 29025879
- The SNPs in TCF7L2 and HHEX were genotyped by polymerase chain reaction-restriction fragment length polymorphism. There were no significant differences in the distribution of genotypes and alleles between polycystic ovary syndrome cases and controls PMID: 26563606
- rs122555372 was associated with pancreatic reserve in patients with type 2 diabetes and with fasting glucose and beta-cell function in individuals without diabetes PMID: 28101933
- TCF7L2 mRNA expression is downregulated in humans with impaired glucose tolerance and adipocyte insulin resistance. PMID: 29317436
- PGC-1alpha induction during differentiation is required for both mitochondrial biogenesis and commitment to the hepatocytic lineage, and TCF7L2 repression is sufficient to increase PGC-1alpha expression, mitochondrial biogenesis and OXPHOS activity. PMID: 28795454
- role in dermal papilla cell proliferation PMID: 24354472
- Silencing the tcf4 gene confers sensitivity to oxaliplatin in colorectal cancer cells. PMID: 24869759
- GRbeta bound to the N-terminus domain of TCF-4 its influence on Wnt signaling required both ligand- and DNA-binding domains. This is enough to maintain the TCF/LEF activity at a high level in the absence of beta-catenin stabilization. PMID: 25301232
- TRIB2 negatively regulates Wnt activity through a reduction in protein stability of TCF4 and beta-Catenin PMID: 25311538
- CtBP physically interacted with TCF-4, and this interaction was significantly inhibited in the presence of MTOB. The above findings point to a novel role of CtBPs in the promotion of CSC growth and self-renewal PMID: 25483087
- Our data revealed that low TCF4 protein expression was a useful predictive factor of good tumor response to nCRT and good outcomes in patients with LARC. PMID: 25519018
- These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers. PMID: 25659031
- KLF5 facilitates lysophosphatidic acid -induced interaction between beta-catenin and TCF4. PMID: 25683913
- The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated beta-catenin by sequestering TCF4 to the nuclear membrane. PMID: 26350900
- Results provides evidence that TCF4 and ZEB1 modulate each other's transcriptional activity in the regulation of tumor pro-invasive Wnt target genes. PMID: 26387539
- The expression of NLK was negatively correlated with TCF4 expression in lung cancers PMID: 26823848
- the beta-catenin/Tcf4 interaction is disrupted by BC-23 PMID: 27014877
- Data show that HMG-box transcription factor 1 protein HBP1-mediated elevation of CDK inhibitor p21 through the Mdm2/p53 and TCF4/EZH2 pathways contributes to both cellular senescence and tumor inhibition. PMID: 27129219
- These results may provide a linkage between PCa chemoresistance and exosome regulatory networks and thus lead us to propose that AR, PTEN and TCF4 genes may be the important genes which are regulated by exosome miRNAs in chemoresistance cancer cells. PMID: 27278879
- G-17 caused the overexpression of beta-catenin and TCF-4. PMID: 27430592
- Taken together, these results suggest that this newly identified Rock2-beta-catenin/TCF4-SCARA5 axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC. PMID: 27793664
- we observed Dickkopf-related protein 3 (DKK3) as a direct target of miR-25 in vitro. Upregulation of DKK3 partially attenuated the oncogenic effect of miR-25 on melanoma cells. Ectopic expression of miR-25 in melanoma cells induced beta-catenin accumulation in nuclear and inhibited TCF4 (T cell factor 4) activity, as well as the expression of c-Myc and Cyclin D1. PMID: 27801786
- FOXN3 bind to beta-catenin and inhibited beta-catenin/TCF signaling by blocking the interaction between beta-catenin and TCF4. Loss of FOXN3 in colon cancer activates beta-catenin/TCF signaling and promotes the growth and migration of cancer cells. PMID: 28039460
- High TCF4 expression is associated with colorectal cancer. PMID: 28921929
- Overexpression of vPK led to reduced mRNA expression of cyclin D1, a well-known transcriptional product of Wnt signaling, suggesting that vPK effectively regulates the host signaling pathway through direct interactions with cellular proteins. PMID: 29432739
- TCF7L2 rs290487, rs6585194, and rs7094463 polymorphisms were found to be significantly associated with gestational diabetes mellitus. PMID: 27465520
- TCF7L2 rs7903146 polymorphism is associated with ischemic heart disease. PMID: 28299838
- The IVS3C>T locus in the TCF7L2 gene is not independently statistically significantly associated with the development of type 2 Diabetes Mellitus in the Kyrgyz population. PMID: 29171469
- six of eight SNPs were found to have significant associations between TCF7L2 variants and gestational diabetes mellitus (GDM) risk in the overall population, with the most powerful SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups - meta-analysis PMID: 28002648
- These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population. PMID: 28404897
- The study found that TCF7L2 SNPs (rs1225404 and rs7003146) might be associated with breast cancer risk in Northwest Chinese Han populations. PMID: 27738320
- These findings further support the hypothesis that TCF7L2 gene variation contributes to diabetogenesis in a subset of young people with Type 1 diabetes. PMID: 27027642
- The rs7903146 variant in the TCF7L2 gene increases the risk of impaired glucose tolerance or type 2 diabetes in obese adolescents by impairing beta-cell function, and hepatic insulin sensitivity predicts the development of impaired glucose tolerance or type 2 diabetes over time. PMID: 28611053
- In conclusion, TCF7L2 regulates estradiol- or progesterone-modulated islet and hepatic glucose metabolism. PMID: 27108846
- TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 might be associated with gestational diabetes risks.[meta-analysis] PMID: 28277135
- Authors found that KIF23 was regulated by TCF-4 at transcriptionally level. Therefore, this evidence indicates KIF23 over-expression is associated with glioma malignancy and conferred a worse survival time in glioma. PMID: 27013586
- findings indicate that the association between TCF7L2 SNP rs12255372 and HDL-C may be modified by dietary fat intake in this Asian Indian population PMID: 29182660
- Wnt Signaling Pathway Effector TCF7L2 plays a role in Glucose Homeostasis. PMID: 27159876
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相關疾病：Diabetes mellitus, non-insulin-dependent (NIDDM)
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亞細胞定位：Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
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蛋白家族：TCF/LEF family
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組織特異性：Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived
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