TBCB Antibody

文獻引用 (1) 說明書

中文名稱：

TBCB兔多克隆抗體
貨號：

CSB-PA03169A0Rb
規格：

￥440
圖片：
Western blot
All lanes: TBCB antibody at 4µg/ml
Lane 1: Hela whole cell lysate
Lane 2: A549 whole cell lysate
Lane 3: Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 22 kDa
Observed band size: 28 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA03169A0Rb at dilution of 1:100

Immunoprecipitating TBCB in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA03169A0Rb in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA03169A0Rb (4µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (20µg)

Immunofluorescent analysis of Hela cells using CSB-PA03169A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TBCB Polyclonal antibody
Uniprot No.：

Q99426
基因名：

TBCB
別名：

CG22 antibody; CKAPI antibody; Cytoskeleton associated protein 1 antibody; Cytoskeleton associated protein CKAPI antibody; Cytoskeleton-associated protein 1 antibody; Cytoskeleton-associated protein CKAPI antibody; Tbcb antibody; TBCB_HUMAN antibody; Tubulin folding cofactor B antibody; Tubulin specific chaperone B antibody; Tubulin-folding cofactor B antibody; Tubulin-specific chaperone B antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tubulin-folding cofactor B protein (1-244AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TBCB Antibody (CSB-PA03169A0Rb)，的標記方式是Non-conjugated。對于TBCB Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA03169B0Rb	TBCB Antibody, HRP conjugated	ELISA
FITC	CSB-PA03169C0Rb	TBCB Antibody, FITC conjugated
Biotin	CSB-PA03169D0Rb	TBCB Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF, IP

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200
IP	1:200-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunoprecipitation (IP) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Dysregulation of a novel miR-1825/TBCB/TUBA4A pathway in sporadic and familial ALS Anika M. Helferich.et al,Cellular and Molecular Life Sciences,2018

產品評價

靶點詳情

功能：

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
基因功能參考文獻：
1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
2. the role of the human TBCE and TBCB chaperones in alpha-tubulin-beta-tubulin dissociation, was investigated. PMID: 25908846
3. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
4. Overexpression of TBCB leads to the decreased localization of p150 to the microtubule network that might result in a functional modulation of this protein complex. PMID: 22777741
5. TBCB localizes at spindle and midzone microtubules during mitosis. PMID: 22940919
6. These findings identified TCoB as the third cytoskeleton protein to be nitrated and suggest a previously undescribed mechanism, whereby growth factor signaling may coordinately integrate nitric oxide signaling in the regulation of microtubule dynamics. PMID: 18048340
7. TBCB functions as a microtubule density regulator in microglia during activation, and provide an insight into understanding of mechanisms controlling microtubule reorganization during microglial transition between phenotypes. PMID: 19038251
8. Study demonstrates that, unlike its counterpart TBCE, TBCB only moderately destabilizes microtubules; neither TBCB abundance nor microtubule organization or densities are altered in giant axonal neuropathy mutant fibroblasts. PMID: 19168853
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton.
蛋白家族：

TBCB family
組織特異性：

Found in most tissues.
數據庫鏈接：

HGNC: 1989

OMIM: 601303

KEGG: hsa:1155

STRING: 9606.ENSP00000221855

UniGene: Hs.31053

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