TAOK2 Antibody, HRP conjugated
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中文名稱：TAOK2兔多克隆抗體, HRP偶聯(lián)
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貨號：CSB-PA892341LB01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TAOK2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：1110033K02Rik antibody; B230344N16 antibody; hKFC C antibody; hKFC-C antibody; KIAA0881 antibody; Kinase from chicken homolog C antibody; MAP3K17 antibody; mKIAA0881 antibody; Prostate derived STE20 like kinase 1 antibody; Prostate derived STE20 like kinase PSK antibody; Prostate derived sterile 20 like kinase 1 antibody; Prostate-derived STE20-like kinase 1 antibody; PSK 1 antibody; PSK antibody; PSK-1 antibody; PSK1 antibody; PSK1 beta antibody; Serine/threonine protein kinase TAO2 antibody; Serine/threonine-protein kinase TAO2 antibody; TAO 1 antibody; TAO 2 antibody; TAO kinase 2 antibody; TAO1 antibody; TAO2 antibody; TAOK 2 antibody; Taok2 antibody; TAOK2_HUMAN antibody; Thousand and one amino acid protein 2 antibody; Thousand and one amino acid protein kinase antibody; UNQ2971/PRO7431 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Serine/threonine-protein kinase TAO2 protein (719-880AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
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基因功能參考文獻：
- we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt PMID: 28830982
- A mutation in TAOK2 appears to cause a novel form of primary immunodeficiency, characterized by an impaired T cell proliferation upon activation. PMID: 28385331
- tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. PMID: 23585562
- TAOK2 is essential for dendrite morphogenesis; TAOK2 downregulation impairs basal dendrite formation without affecting apical dendrites. PMID: 22683681
- PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity PMID: 12639963
- mediates signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors PMID: 12665513
- the TAK1-JNK pathway is activated by osmotic stress, while blocking TAK1-mediated NF-kappaB activation; TAO2 regulates TAK1 pathways PMID: 16893890
- PSK1-alpha is a bifunctional kinase that associates with microtubules, and JNK- and caspase-mediated removal of its C-terminal microtubule-binding domain permits nuclear translocation of the N-terminal region of PSK1-alpha and its induction of apoptosis PMID: 17158878
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亞細胞定位：Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus.
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蛋白家族：Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
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組織特異性：Ubiquitously expressed, with a higher level of expression in testis and brain.
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