TAF3 Antibody

說明書

產品詳情

Uniprot No.：

Q5VWG9
基因名：

TAF3
別名：

140 kDa TATA box-binding protein-associated factor antibody; Bip2 protein antibody; RNA polymerase II transcription factor TAFII140 antibody; TAF(II)140 antibody; TAF140 antibody; TAF3 antibody; TAF3 RNA polymerase II TATA box binding protein (TBP)-associated factor antibody; TAF3_HUMAN antibody; TAFII-140 antibody; TAFII140 antibody; TAFII155 protein antibody; TATA box binding protein associated factor 3 antibody; TBP-associated factor 3 antibody; Transcription initiation factor TFIID 140 kDa subunit antibody; Transcription initiation factor TFIID subunit 3 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human TAF II p140.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.
基因功能參考文獻：
1. Data show that transcription cofactor TAF3 is required for transcription of the alpha spectrin SPTA1 gene. PMID: 23935956
2. Study shows that H3K4me3-TAF3 interactions direct global TFIID recruitment to active genes, some of which are p53 targets. Further analyses show that H3K4me3 enhances p53-dependent transcription by stimulating preinitiation complex formation. PMID: 23452851
3. Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation. PMID: 21884934
4. Data identified TAF3 as an evolutionarily conserved negative regulator of p53 transcription activation function. PMID: 18549481
亞細胞定位：

Nucleus.
蛋白家族：

TAF3 family
數據庫鏈接：

HGNC: 17303

OMIM: 606576

KEGG: hsa:83860

STRING: 9606.ENSP00000340271

UniGene: Hs.527688

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