TAF12 Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TAF12 Polyclonal antibody
Uniprot No.：

Q16514
基因名：

TAF12
別名：

TAF12 antibody; TAF12 RNA polymerase II; TATA box binding protein (TBP)-associated factor; 20kDa antibody; TAF12_HUMAN antibody; TAF15 antibody; TAF2J antibody; TAFII 20/TAFII 15 antibody; TAFII-20/TAFII-15 antibody; TAFII20 antibody; TAFII20/TAFII15 antibody; Transcription initiation factor TFIID 20/15 kDa subunits antibody; Transcription initiation factor TFIID subunit 12 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription initiation factor TFIID subunit 12 protein (1-161AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.
基因功能參考文獻：
1. Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells PMID: 29316427
2. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1 PMID: 27551064
3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
4. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
5. TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. PMID: 17268553
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亞細胞定位：

Nucleus.
蛋白家族：

TAF12 family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 11545

OMIM: 600773

KEGG: hsa:6883

STRING: 9606.ENSP00000263974

UniGene: Hs.530251

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