TAB3 Antibody

中文名稱：

TAB3兔多克隆抗體
貨號：

CSB-PA850806LA01HU
規格：

￥440
圖片：
Immunohistochemistry analysis of human skeletal muscle tissue using CSB-PA850806LA01HU at dilution of 1:100

Immunofluorescent analysis of A549 cells using CSB-PA850806LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TAB3 Polyclonal antibody
Uniprot No.：

Q8N5C8
基因名：

TAB3
別名：

MAP3K7IP 3 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody; NAP1 antibody; NF-kappa-B-activating protein 1 antibody; NFkB activating protein 1 antibody; TAB-3 antibody; Tab3 antibody; TAB3_HUMAN antibody; TAK1 binding protein 3 antibody; TAK1-binding protein 3 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody; TGF-beta-activated kinase 1-binding protein 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 protein (361-712AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TAB3 Antibody (CSB-PA850806LA01HU)，的標記方式是Non-conjugated。對于TAB3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA850806LB01HU	TAB3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA850806LC01HU	TAB3 Antibody, FITC conjugated
Biotin	CSB-PA850806LD01HU	TAB3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; May be an oncogenic factor.
基因功能參考文獻：
1. these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma. PMID: 30226617
2. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome. PMID: 27452334
3. Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis. PMID: 27009840
4. Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells. PMID: 26476534
5. TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB pathway. PMID: 27651027
6. Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. PMID: 26676784
7. miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE PMID: 26555189
8. miR-26b suppresses NF-kappaB signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 and TAB3. PMID: 24565101
9. conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways PMID: 24434549
10. Studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1. PMID: 23286385
11. MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha. PMID: 22660635
12. human TAB2 and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB signalling PMID: 22158122
13. These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1. PMID: 22081109
14. TAB3 is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. PMID: 14633987
15. Identification of TAB3 as a binding partner of the protein kinase TAK1. PMID: 14670075
16. TAB3 transforming growth factor is a constituent of the NF-kappaB pathway functioning upstream of tumor necrosis factor alpha-associated factor 6/transforming growth factor beta-activated kinase PMID: 14766965
17. Data show that TAB2 and TAB3 are receptors that bind preferentially to polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, and activate NF-kappa B and IKK. PMID: 15327770
18. The TAB2/TAB3 interaction with TAK1 is crucial for the activation of signaling cascades mediated by interleukin-1, tumor necrosis factor, and receptor activator of nuclear factor-kappa B ligand (RANKL). PMID: 17158449
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組織特異性：

Widely expressed. Constitutively overexpressed in certain tumor tissues.; [Isoform 1]: Major transcript.; [Isoform 2]: Minor transcript.
數據庫鏈接：

HGNC: 30681

OMIM: 300480

KEGG: hsa:257397

STRING: 9606.ENSP00000288422

UniGene: Hs.188256

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