SYNGAP1 Antibody, Biotin conjugated

說明書

中文名稱：

SYNGAP1兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA857006LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SYNGAP1 Polyclonal antibody
Uniprot No.：

Q96PV0
基因名：

SYNGAP1
別名：

DKFZp761G1421 antibody; KIAA1938 antibody; MRD5 antibody; Neuronal RasGAP antibody; OTTHUMP00000064825 antibody; p135 SynGAP antibody; Ras GTPase activating protein SynGAP antibody; Ras GTPase-activating protein SynGAP antibody; RASA 1 antibody; RASA 5 antibody; RASA1 antibody; RASA5 antibody; SYGP1_HUMAN antibody; Synaptic Ras GAP 1 antibody; Synaptic Ras GTPase activating protein 1 antibody; Synaptic Ras GTPase activating protein 1 homolog antibody; Synaptic Ras GTPase activating protein 135kDa antibody; Synaptic Ras GTPase activating protein antibody; Synaptic Ras GTPase-activating protein 1 antibody; Synaptic Ras-GAP 1 antibody; SYNGAP 1 antibody; SYNGAP1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ras/Rap GTPase-activating protein SynGAP protein (1161-1343AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits.
基因功能參考文獻：
1. De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability. PMID: 26079862
2. This is the first description of a special electroencephalogram phenomenon (normalization with eye opening) in association with SYNGAP1 mutations. PMID: 26110312
3. Syngap transgenic mice exhibited alterations in long-term depression and dendritic spine morphology. PMID: 26558778
4. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. PMID: 25533468
5. Reduced cognition in mutant Syngap1 transgenic mice is caused by isolated damage to developing forebrain neurons. PMID: 24945774
6. De novo CHD2 and SYNGAP1 mutations are new causes of epileptic encephalopathies, accounting for 1.2% and 1% of cases, respectively. PMID: 23708187
7. De novo missense mutations, p.R579X, and possibly all the other truncating mutations in SYNGAP1 result in a loss of its function, causing intellectual disability, autism, and a specific form of epilepsy. PMID: 23161826
8. SYNGAP1 is a brain-specific protein that interacts with key components of the proteins involved in experience-dependent changes in glutamate synapses involved in learning. PMID: 21480541
9. We provide evidence that truncating mutations in SYNGAP1 are common in nonsyndromic intellectual disability and can be also associated with autism. PMID: 21237447
10. The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction. PMID: 18323856
11. Results indicate that SYNGAP1 disruption is a cause of autosomal dominant nonsyndromic mental retardation. PMID: 19196676
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相關疾?。?/div>
Mental retardation, autosomal dominant 5 (MRD5)
數據庫鏈接：

HGNC: 11497

OMIM: 603384

KEGG: hsa:8831

STRING: 9606.ENSP00000403636

UniGene: Hs.586264

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