SYNE2 Antibody, FITC conjugated

說明書

中文名稱：

SYNE2兔多克隆抗體, FITC偶聯
貨號：

CSB-PA841001LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SYNE2 Polyclonal antibody
Uniprot No.：

Q8WXH0
基因名：

SYNE2
別名：

DKFZP434H2235 antibody; DKFZp686E01115 antibody; DKFZp686H1931 antibody; FLJ11014 antibody; FLJ43727 antibody; FLJ45710 antibody; FLJ46790 antibody; KIAA1011 antibody; Nesprin-2 antibody; Nesprin2 antibody; NUA antibody; NUANCE antibody; Nuclear envelope spectrin repeat protein 2 antibody; Nucleus and actin connecting element antibody; Nucleus and actin connecting element protein antibody; Protein NUANCE antibody; Spectrin repeat containing nuclear envelope 2 antibody; Synaptic nuclear envelope protein 2 antibody; Synaptic nuclei expressed gene 2 antibody; SYNE 2 antibody; Syne-2 antibody; SYNE2 antibody; SYNE2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Nesprin-2 protein (1-176AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.
基因功能參考文獻：
1. variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53-indenpdent manner PMID: 27502069
2. The authors identified the nuclear envelope protein nesprin-2 as a binding partner for fascin in a range of cell types in vitro and in vivo. Nesprin-2 interacts with fascin through a direct, F-actin-independent interaction, and this binding is distinct and separable from a role for fascin within filopodia at the cell periphery. PMID: 27554857
3. these data identify N-terminal nesprin-2 variants as novel regulators of beta-catenin signaling. PMID: 27321956
4. We show that AMPH-1/BIN1 binds to nesprin and actin, as well as to the microtubule-binding protein CLIP170 in both species. We propose that BIN1 has a direct and evolutionarily conserved role in nuclear positioning, altered in myopathies. PMID: 26506308
5. The significance of these shorter isoforms of nesprin, were evaluated. PMID: 24718612
6. nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture. PMID: 24931616
7. nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development. PMID: 25516977
8. Each mutation in LMNA has a distinct impact on the Nersprin-2 interaction that substantially explains how distinct mutations in widely expressed genes lead to the formation of phenotypically different diseases. PMID: 23977161
9. High Nesprin-2 expression is associated with colorectal cancer. PMID: 24080406
10. Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds. PMID: 22768332
11. Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex). PMID: 22632968
12. novel isoform, nesprin-2-epsilon, was found to be the major mRNA and protein product of the nesprin-2 gene. PMID: 21820406
13. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development PMID: 20108321
14. Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. PMID: 20801886
15. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. PMID: 19861416
16. Nesprin-2 binds lamin and emerin at the nuclear envelope in skeletal muscle. PMID: 15671068
17. Nesprin-2 has a scaffolding function at the nuclear membrane PMID: 15843432
18. The Nesprin-2 the conserved C-terminal amino acids PPPX is essential for the interaction with a C-terminal region in Sun1. PMID: 16079285
19. The characterisation of the residues both in emerin and in nesprin-1alpha and -2beta which are involved in their interaction is reported. PMID: 17462627
20. Screening for DNA variations in the genes encoding nesprin-1 (SYNE1) and nesprin-2 (SYNE2) in 190 probands with Emery Dreifuss muscular dystrophy identified four heterozygous missense mutations. PMID: 17761684
21. propose nesprin-2 giant as a structural reinforcer at the nuclear envelope in LMNA S143F progeria cells PMID: 17881656
22. Nesprin-2 is an important scaffold protein implicated in the maintenance of nuclear envelope architecture. PMID: 18477613
23. association with human nesprin-3 appeared to be stronger for torsinADeltaE than for torsinA. TorsinA also associated with the KASH domains of nesprin-1 and -2 PMID: 18827015
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相關疾病：

Emery-Dreifuss muscular dystrophy 5, autosomal dominant (EDMD5)
亞細胞定位：

Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass membrane protein. Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplasm. Cytoplasm, myofibril, sarcomere, Z line.
蛋白家族：

Nesprin family
組織特異性：

Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart.
數據庫鏈接：

HGNC: 17084

OMIM: 608442

KEGG: hsa:23224

STRING: 9606.ENSP00000350719

UniGene: Hs.745014

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