SUPV3L1 Antibody, FITC conjugated

說明書

中文名稱：

SUPV3L1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA814232LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SUPV3L1 Polyclonal antibody
Uniprot No.：

Q8IYB8
基因名：

SUPV3L1
別名：

6330443E10Rik antibody; ATP dependent RNA helicase SUPV3L1; mitochondrial antibody; ATP-dependent RNA helicase SUPV3L1 antibody; EC 3.6.1. antibody; MGC109049 antibody; mitochondrial antibody; OTTHUMP00000019719 antibody; S. Cerevisiae suppressor of var 1 3 like 1 antibody; suppressor of var1 (S.cerevisiae) 3 like 1 antibody; Suppressor of var1 3 like 1 (S. cerevisiae) antibody; Suppressor of var1 3 like 1 (S. cerevisiae)(SUV3) antibody; Suppressor of var1 3 like 1 antibody; Suppressor of var1 3 like protein 1 antibody; Suppressor of var1 3-like protein 1 antibody; SUPV 3 L 1 antibody; SUPV3L1 antibody; SUV 3 antibody; SUV 3 L 1 antibody; SUV3 antibody; SUV3 like protein 1 antibody; SUV3-like protein 1 antibody; SUV3_HUMAN antibody; SUV3L1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human ATP-dependent RNA helicase SUPV3L1, mitochondrial protein (499-786AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
基因功能參考文獻：
1. the nucleolar- associated human SUV3 protein is an important factor in regulation of the cell cycle. PMID: 28291845
2. the capacity of hSuv3 DNA unwinding activity might be sensitive to the local availability of specific inorganic cofactors PMID: 25446650
3. SUV3 bridges PNPase and mtPAP to form a transient complex in modulating mt-mRNA poly(A) tail length depending on the mitochondrial matrix Pi level. PMID: 24770417
4. Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation. PMID: 23221631
5. The hSuv3p activity was found to be necessary in the regulation of stability of mature, properly formed mRNAs and for removal of the noncoding processing intermediates transcribed from both H and L-strands. PMID: 19864255
6. Localisation of hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. PMID: 12466530
7. Human SUV3 is an ATP-dependent multiple-substrate helicase; in addition to dsRNA and dsDNA unwinding activity, SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA. PMID: 15096047
8. data suggest that hSUV3 is a housekeeping gene with an enhancer region & regulatory elements in basal promoter PMID: 15919122
9. Suv3 protein interacts with HBXIP, previously identified as a cofactor of survivin in suppression of apoptosis PMID: 16176273
10. Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF- and caspase-dependent, and proceeds with the induction of p53. PMID: 17352692
11. Human SUV3 protein interacts with human WRN and BLM helicases. Silencing of the SUV3 gene in the human cell line HeLa resulted in elevation of homologous recombination as measured by the frequency of sister chromatid exchange during mitotic cell division. PMID: 17961633
12. SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation. PMID: 18678873
13. The complex of hSUV3-hPNPase is an integral entity for efficient degradation of structured RNA and may be the long sought RNA-degrading complex in the mammalian mitochondria. PMID: 19509288
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亞細胞定位：

Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
蛋白家族：

Helicase family
組織特異性：

Broadly expressed.
數據庫鏈接：

HGNC: 11471

OMIM: 605122

KEGG: hsa:6832

STRING: 9606.ENSP00000352678

UniGene: Hs.106469

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