SULF2 Antibody

說(shuō)明書(shū)

中文名稱：

SULF2兔多克隆抗體
貨號(hào)：

CSB-PA810283LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, Mouse brain tissue, Rat lung tissue
All lanes: SULF2 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 101 kDa
Observed band size: 140 kDa

Immunohistochemistry of paraffin-embedded human salivary gland tissue using CSB-PA810283LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA810283LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA810283LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

CUSABIO's product CSB-PA810283LA01HU is a polyclonal antibody against the SULF2 protein. It is produced in the rabbit immunized with the recombinant human extracellular sulfatase SULF2 protein (463-660aa). Its purity reaches up to 95% using protein G purified. This SULF2 antibody has been validated for use in ELISA, WB, IHC, and IF applications. And it reacts with SULF2 proteins from human, mouse, and rat samples.

SULF2 protein is an enzyme that plays a key role in modifying the activity of various signaling molecules in the body. It has been implicated in a number of different physiological and pathological processes, including cancer, inflammation, and cardiovascular disease.
產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SULF2 Polyclonal antibody
Uniprot No.：

Q8IWU5
基因名：

SULF2
別名：

Extracellular sulfatase Sulf 2 antibody; Extracellular sulfatase Sulf-2 antibody; HSulf-2 antibody; HSulf2 antibody; Sulf2 antibody; SULF2_HUMAN antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human Extracellular sulfatase Sulf-2 protein (463-660AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，SULF2 Antibody (CSB-PA810283LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SULF2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA810283LB01HU	SULF2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA810283LC01HU	SULF2 Antibody, FITC conjugated
Biotin	CSB-PA810283LD01HU	SULF2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
基因功能參考文獻(xiàn)：
1. High SULF2 expression is associated with glioma. PMID: 29360432
2. The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate and various growth factors. PMID: 28193024
3. SULF2 promotes the growth and metastasis of CRC probably by activating Akt and Erk1/2 pathways. PMID: 28320104
4. Although no change in SULF2 was detected in squamous cell carcinoma of the head and neck (HNSCC) serum, its detection in saliva makes it worthy of further investigation as a potential HNSCC biomarker. PMID: 27223083
5. results demonstrated that SULF2 can mediate the detrimental effects of ionizing radiation in vivo PMID: 26895473
6. The short variants of Sulf2 promoted FGF2-induced MDA-MB231 and MCF7 in vitro growth while full-length Sulf1 inhibited growth supporting in vivo mammary tumour cell signalling patterns of growth. PMID: 27294358
7. Most pancreatic ductal adenocarcinomas had positive SULF2 staining in tumour cells and intratumoural or tumour-adjacent stroma. Elevated SULF2 in PDAC was associated with advanced tumour stage, vascular invasion, shorter interval to radiological progression and shorter overall survival. PMID: 27560551
8. The SULF1/SULF2 activation thus does not only promote regulated foetal growth and injury-induced liver regeneration but also dysregulated tumour growth. PMID: 27013228
9. Sulf2 facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved. PMID: 27748846
10. renal cell carcinoma with lower SULF-2 expression might have a higher potential for cell invasion and proliferation, leading to a poorer prognosis via the activation of VEGF and/or FGF signaling PMID: 27589337
11. SULF2 is a multifaceted protein involved in triglyceride-rich lipoprotein homeostasis and angiogenesis. [review] PMID: 26959705
12. Our data confirmed that Sulf2 promoted breast cancer progression and regulated the expression of tumor-related genes in breast cancer. PMID: 26708018
13. Tumor expression of SULF2 may affect prognosis in NSCLC, while blood SULF2 levels may have a significant role in the diagnosis of this fatal disease. PMID: 26882224
14. SULF2 have a pro-tumorigenic effect in DU-145 and PC3 cancer cells, suggesting an important role of this enzyme in prostatic cancer metastasis. PMID: 25887999
15. Results show that SULF1 or SULF2 overexpression contributes to colorectal cancer cell proliferation, migration, and invasion. PMID: 25477293
16. Substrate specificity of human SULF2. PMID: 25127119
17. SULF2 blood levels increased with age in both healthy and cirrhosis patients.SULF2 blood level was higher in cirrhosis patients than healthy individuals. PMID: 25444749
18. pectin induced the expression of HSulf-2 through the interaction with fibronectin, alpha5beta1 integrin, and ERK1/2 PMID: 25036960
19. SULF2 expression in human tumor tissue and cell lines, was assessed. PMID: 25325976
20. Our findings define Sulf-2 as a novel positive regulator of neuroblastoma pathogenicity that contributes to MYCN oncogenicity. PMID: 25164011
21. The SULF2 single nucleotide polymorphism was reproducibly associated with lower fasting plasma triglycerides levels in obese type 2 diabetic subjects. PMID: 24339435
22. Results indicate that the genetic variation rs2281279 in SULF2 associates with postprandial clearance of remnant TRLs and triglyceride levels in healthy subjects. PMID: 24278138
23. SULF2 promoter methylation was associated with irinotecan sensitivity in gastric carcinoma. PMID: 24359226
24. SULF1/SULF2 splice variants regulate pancreatic tumor progression. PMID: 24726914
25. SULF2 methylation is negatively associated with cisplatin sensitivity in vitro. PMID: 24124496
26. Knockdown of SULF2 in human corneal epithelial cell line slowed migration, which was restored by overexpression of either mouse SULF2 or human SULF1. PMID: 23950901
27. Ectopic expression of SULF1 or SULF2 in HeLa cells, which decreases cell surface heparan sulfate proteoglycan sulfation, diminished Chlamydia muridarum binding and decreased vacuole formation. PMID: 23480519
28. Sulf2 is overexpressed in idiopathic pulmonary fibrosis and may play a role in regulating TGF-beta1 signaling in type II alveolar epithelial cells. PMID: 23418199
29. studied the functional consequences of HSulf-2 activity on fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities PMID: 23457216
30. Sulf-2 expression is be critical for human breast cancer progression. PMID: 22410125
31. genes and pathways modulated by epigenetic inactivation of SULF2 and the effects on sensitivity to chemotherapy were characterized in lung cancer in vitro and in vivo; silencing SULF2 primarily increased expression of interferon-inducible genes including ISG15 PMID: 22158045
32. Heparan sulfate sulfatase SULF2 regulates PDGFRalpha signaling and growth in human and mouse malignant glioma PMID: 22293178
33. enzymatic activity of HSulf2 PMID: 21347431
34. This study demonstrates that unlike normal adult lung with little or no SULF2 expression, this enzyme is expressed at high levels in most lung tumours showing differential cellular distribution of full length and shorter SULF2 variants in such tumours. PMID: 21968018
35. SULF1 and SULF2 are overexpressed in various human cancer types and can be associated to progression and prognosis. PMID: 21599997
36. The prosurvival, anti-apoptotic effect of SULF2 in hepatocellular carcinoma is mediated through activation of the PI3K/Akt pathway. PMID: 21040406
37. Loss of SULF2 is associated with breast cancer. PMID: 20707913
38. Mechanism mediating the oncogenic function of SULF2 in human hepatoma that includes GPC3-mediated activation of Wnt signaling. PMID: 20725905
39. Our findings support an essential role for Sulf-2 in lung cancer PMID: 19855436
40. Sulfs are extracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment PMID: 12368295
41. HSulf-1 and HSulf-2 have roles in inhibiting myeloma tumor growth PMID: 16192265
42. Purified recombinant Sulf-2 promoted angiogenesis in the chick chorioallantoic membrane assay. PMID: 16331886
43. Binding of VEGF, FGF-1, & certain chemokines (SDF-1 & SLC) to immobilized heparin was abolished or diminished by pre-treating the heparin with HSulf-2. Recombinant or native HSulf-2 released these soluble proteins from their association with heparin. PMID: 16417632
44. Increased sulf-2 mRNA and protein levels may change the sulfation patterns of heparan sulfate proteoglycans and growth factor activities and thus contribute to abnormal chondrocyte activation and cartilage degradation in osteoarthritis. PMID: 18507859
45. Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian development and survival PMID: 18687675
46. Genetic and pharmacologic perturbation of p53 directly influences SULF2 expression in tumor cell lines. PMID: 19190338
47. analysis of the subdomain organization of sulf-1 and sulf-2 PMID: 19520866
48. HSulf-1 (SULF1) and HSulf-2 (SULF2) are potent inhibitors of myeloma tumor growth in vivo. PMID: 16192265
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亞細(xì)胞定位：

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface.
蛋白家族：

Sulfatase family
組織特異性：

Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 20392

OMIM: 610013

KEGG: hsa:55959

STRING: 9606.ENSP00000353007

UniGene: Hs.162016

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